Mixtures of insulin drug-oligomer conjugates comprising...

Details Mixtures of insulin drug-oligomer conjugates comprising... Mixtures of insulin drug-oligomer conjugates comprising...

2006-05-04

2008-12-30

Russel, Jeffrey E (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S303000

Reexamination Certificate

active

07470663

ABSTRACT:
A mixture of conjugates in which each conjugate in the mixture comprises an insulin drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may exhibit higher in vivo activity than a polydispersed mixture of similar conjugates. The mixture may also be more effective at surviving an in vitro model of intestinal digestion than polydispersed mixtures of similar conjugates. The mixture may also result in less inter-subject variability than polydispersed mixtures of similar conjugates.

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