Pharmaceutically active particles of a monomodal particle...

Details Pharmaceutically active particles of a monomodal particle... Pharmaceutically active particles of a monomodal particle...

2002-08-19

2008-11-04

Sheikh, Humera N (Department: 1618)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

C424S400000, C424S451000, C424S452000, C424S456000, C424S464000, C424S465000, C424S490000, C424S497000

Reexamination Certificate

active

07445796

ABSTRACT:
A method of obtaining improved reproducibility of dissolution profiles of dosage forms containing pharmaceutically active particles includes steps of screening raw pharmaceutically active particles to obtain or isolate particles having a desired monomodal particle size distribution. The particles having a monomodal particle size distribution may be incorporated into a solid oral dosage form to provide a highly reproducible dissolution profile. Two or more collections or particles having different monomodal particle size distributions may be combined and incorporated into solid oral dosage forms to provide predictable dissolution profiles.

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