Imidazopyrazine tyrosine kinase inhibitors

Details Imidazopyrazine tyrosine kinase inhibitors Imidazopyrazine tyrosine kinase inhibitors

2004-10-14

2008-12-02

Tucker, Zachary C (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C544S350000, C540S599000

Reexamination Certificate

active

07459554

ABSTRACT:
Compounds of the formulaand pharmaceutically acceptable salts thereof, wherein Q1and R1are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of various diseases and conditions that respond to treatment by inhibition of tyrosine kinases.

REFERENCES:
patent: 5217999 (1993-06-01), Levitzki
patent: 5302606 (1994-04-01), Spada
patent: 5397787 (1995-03-01), Buzzetti
patent: 5556874 (1996-09-01), Dobrusin
patent: 6194439 (2001-02-01), Dow
patent: 6265411 (2001-07-01), Thomas
patent: 6337338 (2002-01-01), Kozlowski
patent: 6362336 (2002-03-01), Lohmann
patent: 6486179 (2002-11-01), Jirousek
patent: 6939874 (2005-09-01), Harmange
patent: 7087602 (2006-08-01), Thomas
patent: 7115617 (2006-10-01), Buchanan
patent: 7202243 (2007-04-01), Hendrix
patent: 7244733 (2007-07-01), Hunt
patent: 7271262 (2007-09-01), La Greca
patent: 7326699 (2008-02-01), Capraro
patent: 7332497 (2008-02-01), Hirst
patent: 7345038 (2008-03-01), Bright
patent: 2004/0014774 (2004-01-01), Myers
patent: 2004/0220189 (2004-11-01), Sun
patent: 2005/0054638 (2005-03-01), Barlaam
patent: 2005/0215564 (2005-09-01), Stiles
patent: 2006/0069084 (2006-03-01), Burns
patent: 2006/0154982 (2006-07-01), Larsson
patent: 2006/0166992 (2006-07-01), Hendrix
patent: 2006/0235031 (2006-10-01), Arnold et al.
patent: 2007/0238734 (2007-10-01), Nemecek
patent: WO 97/28161 (1997-08-01), None
patent: WO 01/72751 (2001-10-01), None
Albert, A. et al. (1970) Journal of the Chemical Society, vol. 11, pp. 1540-1547.
Albert, A. et al. (1969) Chem. Biol.Pterdines.Proc.Int.Symp., 4th, 4:1-5.
Baserga R. (1999) Exp.Cell.Res, vol. 253, pp. 1-6.
Hartz R A et al (2002) Bioorganic & Medicinal Chemistry Letters, vol. 12,pp. 291-294.
Parrizas et al (1997) Endocrinology, vol. 138, pp. 1427-1433.
(1998) Expert Opinion Ther. Pat., vol. 8, pp. 475-478, (Thomas et al).
International Search Report in PCT/US2004/034219, May 6, 2005.
International Preliminary Report on Patentability in PCT/US2004/034219, May 6, 2005.
Written Opinion of the International Search Authority in PCT/US2004/034219, May 6, 2005.
Machine English Translation of JP 07133280, (1995) Akio et al.
Abstract of JP 07133280, Akio et al (1995).

Affiliated with

Also associated with

Rating

Imidazopyrazine tyrosine kinase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Imidazopyrazine tyrosine kinase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Imidazopyrazine tyrosine kinase inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4040799