Surgery – Diagnostic testing – Measuring or detecting nonradioactive constituent of body...
Reexamination Certificate
2005-01-24
2008-12-02
Winakur, Eric F (Department: 3768)
Surgery
Diagnostic testing
Measuring or detecting nonradioactive constituent of body...
C600S316000, C356S300000, C250S252100
Reexamination Certificate
active
07460895
ABSTRACT:
A method for generating a net analyte signal calibration model for use in detecting and/or quantifying the amount of an analyte in a test subject. The net analyte signal can be generated by providing a set of in vivo infrared spectra for a test subject during a period in which an analyte concentration is essentially constant; calculating an optimal subspace of spectra that at least substantially describes all non-analyte dependent spectral variance in the in vivo spectra; providing a pure component infrared spectrum for the analyte; and calculating a net analyte signal spectrum from a data set comprising the optimal subspace spectra and the pure analyte spectrum. The net analyte signal calibration model can be used, for example, in measuring the concentration of analyte in a test subject, and/or for evaluating the analytical significance of an in vivo multivariate calibration model.
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Photonics West presentation, Jan. 24-29, 2004; Brief overview given in the abstract.
Arnold Mark A.
Olesberg Jonathon T.
Ballard Spahr Andrews & Ingersoll LLP
University of Iowa Research Foundation
Winakur Eric F
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