Hydrazine-based and carbonyl-based bifunctional crosslinking...

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Chemical aftertreatment – e.g. – acylation – methylation – etc.

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S174000, C530S409000, C530S810000, C564S019000, C564S036000

Reexamination Certificate

active

07462689

ABSTRACT:
Reagents and methods are provided for crosslinking and immobilizing biomolecules, drugs and synthetic polymers. The reagents possess (i) a thiol or amino reactive group; and (ii) a hydrazino or oxyamino moiety. Conjugates and immobilized biomolecules are also provided.

REFERENCES:
patent: 3808086 (1974-04-01), Mosimann et al.
patent: 4244721 (1981-01-01), Gupta et al.
patent: 4461876 (1984-07-01), Lieberman et al.
patent: 4707440 (1987-11-01), Stavrianopoulos
patent: 4775619 (1988-10-01), Urdea
patent: 4874813 (1989-10-01), O'Shannessy
patent: 5118605 (1992-06-01), Urdea
patent: 5151507 (1992-09-01), Hobbs, Jr. et al.
patent: 5206370 (1993-04-01), Schwartz et al.
patent: 5210203 (1993-05-01), Musso et al.
patent: 5380833 (1995-01-01), Urdea
patent: 5420285 (1995-05-01), Schwartz et al.
patent: 5521290 (1996-05-01), Sivam et al.
patent: 5567624 (1996-10-01), Smith
patent: 5679778 (1997-10-01), Abrams et al.
patent: 5753520 (1998-05-01), Schwartz et al.
patent: 5789576 (1998-08-01), Daily et al.
patent: 5792615 (1998-08-01), Arnold et al.
patent: 5837856 (1998-11-01), Arnold, Jr. et al.
patent: 5837860 (1998-11-01), Anderson et al.
patent: 5854410 (1998-12-01), Arnold, Jr. et al.
patent: 5856571 (1999-01-01), Berninger et al.
patent: 5877220 (1999-03-01), Schwartz et al.
patent: 5880270 (1999-03-01), Berninger et al.
patent: 5900481 (1999-05-01), Lough et al.
patent: 5955597 (1999-09-01), Arnold, Jr. et al.
patent: 5958901 (1999-09-01), Dwyer et al.
patent: 6001826 (1999-12-01), Murrer et al.
patent: 6020526 (2000-02-01), Schwartz et al.
patent: 6028188 (2000-02-01), Arnold, Jr. et al.
patent: 6034135 (2000-03-01), Schwartz et al.
patent: 6133436 (2000-10-01), Köster et al.
patent: 6217845 (2001-04-01), Schwartz et al.
patent: 6238860 (2001-05-01), Whelihan
patent: 6800728 (2004-10-01), Schwartz
patent: 0280474 (1988-08-01), None
patent: 0384769 (1990-02-01), None
patent: 0361768 (1990-04-01), None
patent: 0280474 (1993-11-01), None
patent: WO 93/14779 (1993-08-01), None
patent: 9410149 (1994-05-01), None
patent: 0005208 (2000-02-01), None
patent: 0005243 (2000-02-01), None
patent: 0008042 (2000-02-01), None
patent: 0040590 (2000-07-01), None
patent: 0109385 (2001-02-01), None
patent: WO 01/70685 (2001-09-01), None
Abrams et al., “Technetium-99m-Human Polyclonal lgG Radiolabeled via the Hydrazino Nicotinamide Derivative for Imaging Focal Sites of Infection in Rats”,J. Nucl. Med., 31(12):2022-2028; (1990).
Agrawal, S. (Ed.),Methods in Molecular Biology.20, Book: Protocols for Oligonucleotides and Analogs, Synthesis and Properties, Humana Press, (1993), pp. ix-xi.
Bischoff et al., “Introduction of 5′-Terminal Functional Groups into Synthetic Oligonucleotides for Selective Immobilization”,Anal. Biochem., 164:336-344; 1987).
Bridger et al., “A Comparison of Cleavable and Noncleavable Hydrazinopyridine Linkers for the99mTc Labeling of Fab′ Monoclonal Antibody Fragments”,Bioconj. Chem., 7:255-264; (1996).
Chang et al., “Early Results in the International Design of New Bifunctional Chelators”,6th Conference on Radioimmunodetection and Radioimmunotherapy of Cancer—Supplement to Cancer, 80:2347-2353; (1997).
Ellis et al., “Development and Clinical Uses of Haemphilus b Conjugate Vaccines”, Book:Marcel Dekker, Inc.; New York; (1994), pp. xi-xii.
Ghosh et al., “Covalent attachment of oligonucleotides to solid supports”,Nucl. Acids. Res., 15(3):5353-5372; (1987).
Ghosh et al., “Synthesis of 5′-Oligonucleotide Hydrazide Derivatives and Their Use in Preparation of Enzyme-Nucleic Acid Hybridization Probes”,Anal. Biochem., 178:43-51; (1989).
Greene et al., “Protective Groups in Organic Synthesis”, Book: 2nd Edition,John Wiley&Sons, Inc., pp. ix-x (1991).
Hermanson et al.,Bioconjugate Techniques: Academic Press, 1996, pp. vii-xxiii.
Hostomsky et al., “Solid-phase assembly of DNA duplexes from synthetic oligonucleotides,”Nucl. Acid. Symp. Ser., 18:241-244; (1987).
IUPAC-IUB: “IUPAC-IUB Commission on Biochemical Nomenclature Abbreviated Nomenclature of Synthetic Polypeptides (Polymerized Amino Acids)”,Biochem., 11(5):942-944; (1972).
Kaneko et al., “New Hydrazone Derivates of Adriamycin and Their Immunoconjugates—a Correlation between Acid Stability and Cytotoxicity,”Bioconj. Chem., 2(3):133-141; (1991).
King et al., “Preparation of Protein Conjugates via Intermolecular Hydrazone Linkage”,Biochem., 25:5774-5779; (1986).
Marble et al., “RNA Transcription from Immobilized DNA Templates,”Biotechnol. Prog.11:393-396; (1995).
Reynolds et al., “Antisense oligonucleotides containing an internal non-nucleotide-based linker promote site-specific cleavage of RNA”,Nucl. Acids. Res., 24(4):760-765; (1996).
Reynolds et al., “Synthesis and thermodynamics of oligonucleotides containing chirally pure Rp methylphosphonate linkages”,Nucl. Acids. Res.24(22):4584-4591; (1996).
Rose et al., “Natural Peptides as Building Blocks for the Synthesis of Large Protein-like Molecules with Hydrazone and Oxime Linkages”,Bioconjugate Chem., 7:552-556; (1996).
Salo et al., “Aminooxy Functionalized Oligonucleotides: Preparation, On-Support Derivatization, and Postsynthetic Attachment to Polymer Support”,Bioconjugate Chem., 10:815-823; (1999).
Schwartz et al., “Preparation of Hydrazino-Modified Proteins and Their Use for the Synthesis of 99mTc-Protein Conjugates,”Bioconjugate Chem., 2:333-336; (1991).
Timofeev et al., “Regioselective immobilization of short oligonucleotides to acrylic copolymer gels”,Nucl. Acids. Res., 24(16):3142-3148; (1996).
Trevisiol et al., “The Oxyamino-Aldehyde Coupling Reaction: An Efficient Method for the Derivatization of Oligonucleotides”,Tetrahedron Lett, 38(50):8687-8690; (1997).
Trevisiol et al., “Synthesis of Nucleoside Triphosphate that Contain an Aminooxy Function for ‘Post-Ampification Labeling’”,Eur. J. Org. Chem., pp. 211-217; (2000).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Hydrazine-based and carbonyl-based bifunctional crosslinking... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Hydrazine-based and carbonyl-based bifunctional crosslinking..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hydrazine-based and carbonyl-based bifunctional crosslinking... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4038406

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.