Combination product comprising melagatran and dexamethasone

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Details

C514S020800, C514S247000, C424S009100, C544S238000, C544S239000, C544S240000, C560S034000, C560S035000, C560S168000, C560S169000, C562S439000, C562S560000

Reexamination Certificate

active

07449446

ABSTRACT:
There is provided a combination product comprising; (A) melagatran or a pharmaceutically acceptable derivative thereof; and (B) dexamethasone or a pharmaceutically acceptable derivative there of, wherein each of components (A) and (B) is formulated in admixture with a pharmaceutically-acceptable adjuvant, diluent or carrier, as well as the use of such a combination product in the treatment of conditions including disseminated intravascular coagulation.

REFERENCES:
patent: 3461208 (1969-08-01), Winter
patent: 6683054 (2004-01-01), Kirk
patent: WO-94/29336 (1994-12-01), None
patent: WO-97/23499 (1997-07-01), None
patent: WO 00/64470 (2000-04-01), None
patent: WO-00/41716 (2000-07-01), None
patent: WO-01/95931 (2001-12-01), None
patent: WO-01/95932 (2001-12-01), None
Yi et al., Inflammation vol. 20, No. 2 , 165-175 (1996).
Bernard et al., “Efficacy and Safety of Recombinant Human Activated Protein C. For Severe Sepsis,” The New England Journal of Medicine 344(10):699-709 (2001).
Saito et al., “Recombinant Hirudin for the Treatment of Disseminated Intravascular Coagulation in Patients with Haematological Malignancy,” Blood Coagulation and Fibrinolysis 6:60-64 (1995).
Yamazaki et al., “Prednisolone Inhibits Endotoxin-Induced Disseminated Intravascular Coagulation and Improves Mortality in Rats: Importance of Inflammatory Cytokine Suppression,” Blood Coagulation and Fibrinolysis 10:321-330 (1999).
Eisele, B., et al., “Clinical Experience with Antithrombin III Concentrates in Critially Ill Patients with Sepsis and Multiple Organ Failure,” Sem. Thromb. Hemost., 24, 71-80 (1998).
Riewals, M., et al., “Treatment Options for Clinically Recognized Disseminated Intravascular Coagulation,” Sem. Thromb. Hemost., 24, 53-59 (1998).
Diaz-Cremades, J.M., et al., “Use of antithrombin III in critcal patients,” Intensive Care Med., 20, 577-580 (1994).
Eriksson, M., et al., “Melagatran, a Low Molecular Weight Thrombin Inhibitor, Counteracts Endotoxin-induced Haemodynamic and Renal Dysfunctions in the Pig,” Thromb. Haemost., 80-1022-1026 (1998).
Erikkson, M., et al., “Effects of melagatran, an inhibitor of thrombin, on fibrin deposits, haemodynamics, and platelet count in endotoxaemic pigs,” Acta Anaesthesiol. Scand., 44, 24-31 (2000).
Basu, S., et al., “Effects of melagatran, a novel direct thrombin inhibitor, during experimental septic shock,” Exp. Opin. Invest. Drugs, 9(5), 1129-1137 (2000).
Martindale—The Complete Drug Reference, 32nd Edition, K. Parfitt (ed.), Pharmaceutical Press, London (1999), 1037-1039.
“Melagatran and Ximelagatran, Anticoagulant Thrombin Inhibitor,” Drugs of the Future, 26(12), 1155-1170 (2001).
Margareta, E., et al., “A combination of a thrombin inhibitor and dexamethasone prevents the development of experimental disseminated intravascular coagulation in rats,” Abstract—Blood, http://www.bloodjournal.org, vol. 98(11), p. 47a, (Nov. 2001).
Liu, Y.Y., “Comparison between the therapeutic effects of ginseng-aconitum-bupleurum injection and dexamethasone on septic shock complicated with disseminated intravascular coagulation induced byE. coliin dogs,” Chung Hsi I Chieh Ho Tsa Chih Chinese Journal of Modern Developments in Traditional Medicine, 10(11), 675-6, 645 (1990), STN International, File: Medline, accession No. 91098744.
coagulation induced by E. coil in dogs, Chung Hsi I Chieh Ho Tsa Chih Chinese Journal of Modern Developments in Traditional Medicine, 10(11), 675-6, 645 (1990), STN International, File: Medline, accession no. 91098744.

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