Combined ambient desorption and ionization source for mass...

Details Combined ambient desorption and ionization source for mass... Combined ambient desorption and ionization source for mass...

2006-04-28

2008-12-09

Berman, Jack I (Department: 2881)

Radiant energy

Ionic separation or analysis

With sample supply means

C250S281000, C250S282000, C250S283000, C250S287000, C250S42300F, C250S424000, C250S324000, C422S907000, C436S173000

Reexamination Certificate

active

07462824

ABSTRACT:
Combined desorption and ionization sources are provided to generate molecular ions form a sample disposed on a substrate surface. A heated gas-jet probe or heated solvent stream probe desorbs sample molecules into the gas phase. The desorbed sample molecules are ionized by reaction between the sample molecule and charged solvent droplets. The charged solvent droplets may be produced by electrospray probe or by a corona discharge. The combined desorption and ionization sources coupled by a vacuum interface to a mass spectrometer, where the sample molecule ions can be analyzed.

REFERENCES:
McEwen Charles N., McKay Richard G., Larsen Barbara S. “Analysis of solids, liquids, and biological tissues using solids probe□□introduction at atmospheric pressure on commercial LC/MS instruments”, Anal. Chem. 2005 vol. 77 No. 23, pp. 7826-7831.

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