Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1983-03-07
1987-08-11
Lesmes, George F.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
544 60, 544137, 546146, 546168, 546209, 546275, 548200, 548227, C07D26344
Patent
active
046862951
ABSTRACT:
This invention relates to new compounds of the formula ##STR1## wherein A is a hydroxy, lower alkoxy, lower alkenoxy, diloweralkylamino lower alkoxy, acylamino lower alkoxy, acyloxy, lower alkoxy, aryloxy, arloweralkyloxy, amino, loweralkylamino, diloweralkylamino, aryloweralkylamino, hydroxyamino, or substituted aryloxy, or substituted arloweralkoxy wherein the substituent is methyl, halo or methoxy;
R.sub.1, R.sub.2, and R.sub.3 are each hydrogen, lower alkyl, lower alkenyl, lower alkynyl, aryl, fused aryl-cycloalkyl, aralkyl, cycloalkyl, heterocyclic, substituted alkyl, alkenyl, or alkynyl groups in which the substituents are hydroxy, alkoxy, halo, amino, aminoalkyl, alkylamino, mercapto, or alkylmercapto, substituted cycloalkyl groups in which the substituents are alkyl, halo, haloalkyl, hydroxy, alkylamino, nitro or trifluoromethyl, and substituted aryl and heterocyclic groups in which the substituents are alkyl, hydroxy, alkoxy, hydroxyalkyl, halo, mercapto, alkylmercapto, mercaptoalkyl, haloalkyl, amino, alkylamino, aminoalkyl, nitro, methylenedioxy, or trifluoromethyl;
X is hydrogen, alkyl, alkenyl or alkynyl of up to about 20 carbon atoms, aryl or aryl lower alkyl containing from about 7 to about 12 carbon atoms, heterocyclic or heterocyclic lower alkyl cycloalkyl or cycloalkylalkyl containing up to about 20 carbon atoms, or of the formula: ##STR2## wherein n=2, 3 or 4;
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Jones Howard
Skiles Jerry W.
Suh John T.
Youssefyeh Raymond D.
Gibson S. A.
Lesmes George F.
USV Pharmaceutical Corporation
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