Process for the preparation of isonicotinic acid derivatives

Details Process for the preparation of isonicotinic acid derivatives Process for the preparation of isonicotinic acid derivatives

2005-10-27

2008-12-02

Davis, Zinna N (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07459563

ABSTRACT:
The present invention relates to a process for the manufacture of compounds of formula Ia or Iband pharmaceutically acceptable additional salts thereof, wherein R is lower alkyl. The compounds of formula Ia or Ib are valuable intermediate products for the manufacture of compounds that are pharmaceutically active as adenosine A2a receptor antagonist or metabotropic Glutamate receptor 2 antagonist. Such compounds are important in the regulation of many aspects of cellular metabolism and in the modulation of different central nervous system activities.

REFERENCES:
patent: 3725428 (1973-04-01), Janiak
patent: 4028374 (1977-06-01), Pelose, Jr. et al.
patent: 4471957 (1984-09-01), Engalitcheff, Jr.
patent: 5099021 (1992-03-01), Worther et al.
patent: 5142910 (1992-09-01), Litchmann
patent: 5275045 (1994-01-01), Johnston et al.
patent: 5312107 (1994-05-01), Gvoich et al.
patent: 5348519 (1994-09-01), Prince et al.
patent: 5439225 (1995-08-01), Gvoich et al.
patent: 6521754 (2003-02-01), Alanine et al.
patent: 6548495 (2003-04-01), Adam et al.
patent: 6620811 (2003-09-01), Flohr et al.
patent: 6835732 (2004-12-01), Alanine et al.
patent: 6963000 (2005-11-01), Alanine et al.
patent: 2003/0134854 (2003-07-01), Flohr et al.
patent: 2005/0026906 (2005-02-01), Alanine et al.
patent: 2006/0003986 (2006-01-01), Alanine et al.
patent: 1953149 (1970-05-01), None
patent: 113219 (1984-07-01), None
patent: 0199400 (1986-10-01), None
patent: 295656 (1988-12-01), None
patent: 0295656 (1988-12-01), None
patent: 0343893 (1989-11-01), None
patent: 0404440 (1990-12-01), None
patent: 427963 (1991-05-01), None
patent: 0604657 (1994-07-01), None
patent: 2753970 (1998-04-01), None
patent: 1345552 (1974-01-01), None
patent: 1538822 (1979-01-01), None
patent: WO 99/24035 (1999-05-01), None
patent: WO 99/37630 (1999-07-01), None
patent: WO 00/18767 (2000-04-01), None
patent: WO 00/27819 (2000-05-01), None
patent: WO 01/10846 (2001-02-01), None
patent: WO 01/19360 (2001-03-01), None
patent: WO 01/29011 (2001-04-01), None
patent: WO 01/29012 (2001-04-01), None
patent: WO 01/97786 (2001-12-01), None
patent: WO 02/083665 (2002-10-01), None
patent: WO 03/043636 (2003-05-01), None
Johnson et al., Journal of the Chemical Society, p. 796-880, (1970).
Bardhan, J., Journal of the Chemical Society, p. 2223-2232 (1929).
Locicero, et al., Journal of the American Chem. Society, vol. 74, pp. 2094-2097 (1952).
Colotta, et al., Arch. Pharm. Med. Chem. vol. 332, pp. 39-41 (1999).
Baraldi, et al., J. Med. Chem. vol. 39, pp. 1164-1171 (1996).
Li et al., J. Med. Chem. vol. 42, pp. 706-721 (1999).
Kim et al., J. Med. Chem. vol. 41, pp. 2835-2845 (1998).
Li et al., J. Med. Chem. vol. 41, pp. 3186-3201 (1998).
Baraldi, et al., J. Med. Chem. vol. 41, pp. 2126-2133 (1998).
Poulsen et al., Bioorganic & Medicinal Chem. vol. 6, pp. 619-641 (1998).
Müller et al., Bioorganic & Medicinal Chem., vol. 6, pp. 707-719 (1998).
Patent Abstracts of Japan, No. 10, (1999), JP11130761A.
Pandeya, et al., Indian Drugs, vol. 23(3), pp. 146-151 (1985).
Daidone et al., Il Farmaco vol. 44, No. 5, pp. 465-473 (1989).
The Merck Index, 12thEd. P. 506, (1996).
Bellamy et al., Tetrahedron Letters, vol. 25, No. 8, pp. 839-842 (1984).
Achmatowicz et al., Tetrahedron, vol. 27, pp. 1973-1996 (1971).
Boyer et al., J. Heterocyclic Chem. vol. 25, pp. 1003-1005 (1988).
Ohmori et al., J. Med. Chem. vol. 37, pp. 467-475 (1994).
Ishikawa et al., J. Med. Chem. vol. 28, pp. 1387-1393 (1985).
Fanta et al., Organic Synthesis, vol. 25, pp. 78-80 (1945).
Corey et al., J. Org. Chem. vol. 38, No. 18, p. 3224 (1973).
Eicher et al., Synthesis, pp. 755-762 (1996).
Widmer, Synthesis pp. 135-136 (1983).
Bowman et al., Org. Prep. Proc. Int. Briefs vol. 22, No. 5, pp. 636-638 (1990).
Quallich et al., Synthesis, pp. 51-53 (1993).
Auchampach et al., Am. J. Physiol., vol. 276, pp. H1113-H1116 (1999).
Haas et al., Naunyn Schmiedeberg's Arch. Pharmacol. vol. 362, pp. 375-381 (2000).
Dionisotti et al., Br. J. Pharmacol. vol. 121, pp. 353-360 (1997).
Abstract corresponding to FR 2753970 (B9), (1998).
Abstract corresponding to WO 00/27819 (B12), (2000).
Ragan, JA, et al., Synthesis, No. 4, pp. 483-486 (2002).

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