Method and apparatus for muscle function measurement

Details Method and apparatus for muscle function measurement Method and apparatus for muscle function measurement

2005-01-26

2008-12-30

Marmor, II, Charles A (Department: 3735)

Surgery

Diagnostic testing

Cardiovascular

C600S587000

Reexamination Certificate

active

07470233

ABSTRACT:
The present invention provides an apparatus and method for monitoring muscle function based on an index derived from a pressure or force signal. The muscle function index is derived from an instantaneous muscle stiffness ratio computed as the ratio of the first time derivative of the pressure or force waveform to the corresponding instantaneous pressure or force. The instantaneous stiffness ratio, Ė/E(t), is in units of 1/sec and relates to the rate of strong bond formation and will be influenced by calcium handling properties of the muscle fibers and the intracellular calcium concentration. As such, an index derived from Ė/E(t) provides a measure of the inotropic status of the muscle.

REFERENCES:
patent: 3815611 (1974-06-01), Denniston, III
patent: 4485813 (1984-12-01), Anderson et al.
patent: 4566456 (1986-01-01), Koning et al.
patent: 4936304 (1990-06-01), Kresh et al.
patent: 5129394 (1992-07-01), Mehra
patent: 5271392 (1993-12-01), Ferek-Petric
patent: 5368040 (1994-11-01), Carney
patent: 5417717 (1995-05-01), Salo et al.
patent: 5496351 (1996-03-01), Plicchi et al.
patent: 5564434 (1996-10-01), Halperin et al.
patent: 5693074 (1997-12-01), Ferek-Petric
patent: 5743267 (1998-04-01), Nikolic et al.
patent: 5758652 (1998-06-01), Nikolic et al.
patent: 5800464 (1998-09-01), Kieval
patent: 6438408 (2002-08-01), Mulligan et al.
patent: 6795732 (2004-09-01), Stadler et al.
patent: 6915162 (2005-07-01), Noren et al.
patent: 6939303 (2005-09-01), Curiel
patent: 2002/0138009 (2002-09-01), Brockway et al.
patent: 2003/0092998 (2003-05-01), Curiel
patent: 2004/0215049 (2004-10-01), Zdeblick et al.
patent: 2004/0220638 (2004-11-01), Mulligan et al.
patent: 2005/0182330 (2005-08-01), Brockway et al.
patent: WO 02/053228 (2002-07-01), None
Grossman et al., “new Technique for Determining Instantaneous Myocardial Force-Velocity Relations in the Intact Heart”, Circulation Research, vol. 28, 1971, pp. 290-297.
Mirsky et al., “Coreection for preload in assessment of mycardial contractility in aortic and mitral valve disease. Application of the concept of systolic myocardial stiffness”, Circulation, vol. 78, 1988 pp. 68-80.
Quinones et al., “Influence of acute changes in preload, afterload, contractile state and heart rate on ejection and isovolumic indices of mycardial contractility in man”, Circulation, vol. 53, No. 2, Feb. 1976, pp. 293-302.
“Assessment of Cardiac Contractility; The Relation Between the Rate of Pressure Rise and Ventricular Pressure During Isovolumic Systole,” Circulation, vol. 44, pp. 47-58 (1971).

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