Chemistry: analytical and immunological testing – Food or dairy products
Patent
1986-10-08
1989-06-06
Hill, Jr., Robert J.
Chemistry: analytical and immunological testing
Food or dairy products
73 611C, 2101982, 210260, 21032171, 21032172, 21032175, 210656, 210659, 422 70, 436 89, 436 98, 436161, 436178, 436179, G01N 128, G01N 3008, G01N 3014, G01N 3302
Patent
active
048371572
ABSTRACT:
A plurality of analytes are analyzed by liquid chromatography in a liquid biological sample containing many components which can interfere with analysis by liquid chromatography. The sample, containing the analytes of interest, are passed to a first passage of a dialyzer which removes molecules in the sample which interfere with analysis. A diluent is passed through a second passage of the dialyzer in which the two liquids are separated from each other by a semipermeable membrane having holes large enough to permit the analytes of interest to pass into the diluent but holes small enough to prevent passage of sample components which interfere with analysis. The analyte-containing diluent is passed to a retaining element for temporarily retaining the analytes of interest by adsorption and/or partition. The analytes of interest are removed from the retaining element by a second diluent which is then passed through a chromatography column with a detector and the analytes are analyzed chromatographically. The portion of the sample containing the interfering molecules is discarded.
REFERENCES:
patent: 4824 (1846-10-01), Read
patent: 2502614 (1950-04-01), Zender
patent: 2789654 (1957-04-01), Zurit
patent: 3211645 (1965-10-01), Ferrari
patent: 3352644 (1967-11-01), Lysyj
patent: 3572994 (1971-03-01), Hochstrasser
patent: 3625652 (1971-12-01), Fujimoto et al.
patent: 3668936 (1972-06-01), Herron
patent: 3879127 (1975-04-01), Storr et al.
patent: 4054648 (1977-10-01), Nagasawa et al.
patent: 4070284 (1978-01-01), Fujita et al.
patent: 4108608 (1978-08-01), Maher, Jr. et al.
patent: 4137307 (1979-01-01), Funakoshi et al.
patent: 4267056 (1981-05-01), McClure
patent: 4269708 (1981-05-01), Bonomini et al.
patent: 4444661 (1984-04-01), Jackson et al.
patent: 4528158 (1985-07-01), Gilles et al.
Burns, Donald A.; Fast-LC Concepts for Automated Pesticide Analysis; Pesticide Analytical Methodology; ACS Symposium Series 136; Washington, D.C., 1980.
Mohammed et al, Chemical Abstracts, vol. 96, Abstract No. 96:65079j, 1981.
Knudson et al, Clin. Chem., vol. 24, No. 4, pp. 686-691, 1978.
Mohammed et al, J. of Chromatography, vol. 226, pp. 471-476 (1981).
Cooper John D. H.
Turnell David C.
Coventry Health Authority
Hill Jr. Robert J.
LandOfFree
Sample preparation method for liquid chromatography does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Sample preparation method for liquid chromatography, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sample preparation method for liquid chromatography will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-40319