Methods of preventing or treating graft versus host reaction...

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,...

Reexamination Certificate

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C424S133100, C424S135100, C424S141100, C424S142100, C424S143100, C530S387100, C530S387300, C530S388100, C530S388150, C530S388200

Reexamination Certificate

active

07465445

ABSTRACT:
An antibody against AILIM (alternatively called JTT-1 antigen, JTT-2 antigen, ICOS and 8F4) was found to have a significant therapeutic effect on arthrosis, for example, rheumatoid arthritis and osteoarthritis, graft versus host disease, graft immune rejection, inflammation (hepatitis and inflammatory bowel diseases), diseased condition accompanied by the excessive production of an antibody against a foreign antigen triggered by immunological sensitization by the antigen.

REFERENCES:
patent: 5484892 (1996-01-01), Tedder et al.
patent: 5506126 (1996-04-01), Seed et al.
patent: 5521288 (1996-05-01), Linsley et al.
patent: 5747461 (1998-05-01), Markov
patent: 5770197 (1998-06-01), Linsley et al.
patent: 5914112 (1999-06-01), Bednar et al.
patent: 6075181 (2000-06-01), Kucherlapati
patent: 6440418 (2002-08-01), Black et al.
patent: 6531505 (2003-03-01), Xu et al.
patent: 2002/0115831 (2002-08-01), Tamatani et al.
patent: 2002/0151685 (2002-10-01), Tamatani et al.
patent: 2002/0156242 (2002-10-01), Tamatani et al.
patent: 2002/0164697 (2002-11-01), Coyle et al.
patent: 2002/0177191 (2002-11-01), Kroczek
patent: 2002/0182667 (2002-12-01), Kroczek
patent: 2003/0083472 (2003-05-01), Tamatani et al.
patent: 13320/99 (1999-04-01), None
patent: 198 21 060 (1999-04-01), None
patent: 19821060 (1999-04-01), None
patent: 0 984 023 (2000-03-01), None
patent: 1 125 585 (2001-08-01), None
patent: 5-72204 (1993-03-01), None
patent: 11-228442 (1999-08-01), None
patent: 2000-154151 (2000-06-01), None
patent: WO 95/33770 (1995-12-01), None
patent: WO 97/26912 (1997-07-01), None
patent: WO 98/11909 (1998-03-01), None
patent: WO 98/19706 (1998-05-01), None
patent: WO 98/30232 (1998-07-01), None
patent: WO 98/37415 (1998-08-01), None
patent: WO 98/38216 (1998-09-01), None
patent: WO 98/45331 (1998-10-01), None
patent: WO 98/52606 (1998-11-01), None
patent: WO 99/15553 (1999-04-01), None
patent: WO 00/19988 (2000-04-01), None
patent: WO 00/46240 (2000-08-01), None
patent: WO 00/67788 (2000-11-01), None
patent: WO 01/08700 (2001-02-01), None
patent: WO 01/12658 (2001-02-01), None
patent: WO 01/15732 (2001-03-01), None
patent: WO 01/18022 (2001-03-01), None
patent: WO 01/21796 (2001-03-01), None
patent: WO 01/32675 (2001-05-01), None
patent: WO 01/64704 (2001-09-01), None
patent: WO 01/87981 (2001-11-01), None
patent: WO 02/44364 (2002-06-01), None
patent: WO 02/070010 (2002-09-01), None
patent: WO 02/076504 (2002-10-01), None
Huang Z., Pharmacology and Therapeutics, 2000, 86: 201-215.
Attwood T., Science 2000; 290:471-473.
Skolnick et al., Trends in Biotech. 2000; 18(1):34-39.
Metzler et al., Nature Structural Biol. 1997; 4:527-531.
Iwai et al. (2002) “Amelioration of Collagen-Induced Arthritis by Blockade of Inducible Costimulator-B7 Homologous Protein Costimulation,” J. Immunol., 169(8):4332-39.
Aicher et al., “Characterization of Human Inducible Costimulator Ligand Expression and Function,” J. Immunol., 164(9):4689-4696 (2000).
Bajorath “A molecular model of inducible costimulator protein and three-dimensional analysis of its relation to the CD28 family of T cell-specific costimulatory receptors,” J. Mol. Model. 5:169-176 (1999).
Beier et al., “Induction, binding specificity and function of human ICOS,” Eur. J. Immunol., 30(12):3707-3717 (2000).
Brodie et al., “LICOS, a primordial costimulatory ligand?,” Curr. Biol., 10(6):333-336 (2000).
Buonfiglio et al., “Characterization of a novel human surface molecule selectively expressed by mature thymocytes, activated T cells and subsets of T cell lymphomas,” Eur. J. Immunol., 29(9)2863-2874 (1999).
Buonfiglio et al., “The T cell activation molecule H4 and the CD28-like molecule ICOS are identical,” Eur. J. Immunol. 30(12):3463-3467 (2000).
Cameron “Recent advances in transgenic technology” Molecular Biotechnology 7:253-65 (1997).
Chambers, “The expanding world of co-stimulation: the two-signal model revisited,” Trends in Immunology, 22(4):217-223 (2001).
Cocks et al. “A novel receptor involved in T-cell activation,” Nature, 376:260-263 (Jul. 20, 1995).
Coyle et al., “The CD28-Related Molecule ICOS Is Required for Effective T Cell-Dependent Immune Responses,” Immunity 13(1):95-105 (2000).
Dong et al., “Cutting Edge: Critical Role of Inducible Costimulator in Germinal Center Reactions,” J. Immunol., 166(6):3659-3662 (2001).
Dong, “ICOS co-stimulatory receptor is essential for T-cell activation and function,” Nature 409(6816):97-101 (2001).
Gonzalo et al., “The Related Molecules CD28 and Inducible Costimulator Deliver Both Unique and Complementary Signals Required for Optimal T Cell Activation,” J. Immunol., 166(1):1-5 (2001).
Guo et al., “Stimulatory Effects of B7-Related Protein-1 on Cellular and Humoral Immune Responses in Mice,” J. Immunol., 166(9):5578-5584 (2001).
Hanzawa et al., “Characteristics of a TTH1 antibody which blocks an unknown adhesion phenomenon,” Proceedings of the Japanese Society for Immunology, vol. 24, Abstract No. W17-13 (1994) [Original Japanese and English Language Translation].
Heyeck et al. “Developmental regulation of a murine T-cell -specific tyrosine kinase gene, Tsk,” Proc. Natl. Acad. Sci. USA, vol. 90, pp. 669-673 (1993).
Houdebine “Production of pharmaceutical proteins from transgenic animals” J. Biotechnol. 34:269-87 (1994).
Hutloff et al., “ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28,” Nature, 397(6716):263-266 (1999).
Ishikawa et al., “Prediction of the Coding Sequences of Unidentified Human Genes. X. The Complete Sequences of 100 New cDNA Clones from Brain Which Can Code for Large Proteins in vitro,” DNA Research, 5:169-176 (1998).
Kappel et al. “Regulating gene expression in transgenic animals” Current Opinion in Biotechnology 3:548-53 (1992).
Kopf et al., “Inducible Costimulator Protein (ICOS) Controls T Helper Cell Subset Polarization after Virus and Parasite Infection,” J. Exp. Med., 192(1):53-61 (2000).
Kuchroo et al. “B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy,” Cell, 80:707-718 (Mar. 10, 1995).
Ling et al., “Cutting Edge: Identification of GL50, a Novel B7-Like Protein That Functionally Binds to ICOS Receptor,” J. Immunol., 164(4):1653-1657 (2000).
Mages et al., “Molecular cloning and characterization of murine ICOS and identification of B7h as ICOS ligand,” Eur. J. Immunol., 30(4):1040-1047 (2000).
Marguet et al. “cDNA Cloning for Mouse Thymocyte-activating Molecule,” The Journal of Biological Chemistry, vol. 267, No. 4, pp. 2200-2208 (1992).
McAdam et al., “Mouse inducible costimulatory (ICOS) molecule expression is increased by CD28 costimulation and regulates development of Th2 cells,” FASEB Journal, 14(6):A1169 (2000).
McAdam, “ICOS is critical for CD40-mediated antibody class switching,” Nature 409(6816):102-105 (2001).
McAdam, “Mouse Inducible Costimulatory Molecule (ICOS) Expression Is Enhanced by CD28 Costimulation and Regulates Differentiation of CD4+T Cells,” J. Immunol., 165(9):5035-5040 (2000).
Mueller, “T cells: A proliferation of costimulatory molecules,” Curr. Biol. 10(6):R227-R230 (2000).
Mullins et al. “Expression of the DBA/2J Ren-2 gene in the adrenal gland of transgenic mice” EMBO J., 8:4065-72 (1989).
Mullins et al. “Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene” Nature, 344:541-44 (1990).
Mullins et al. “Transgenesis in nonmurine species” Hypertension 22:630-33 (1993).
Niemann “Transgenic farm animals get off the ground” Transgenic Research, 7:73-75 (1998).
Nojima et al. “The 4F9 antigen is a member of the tetra spans transmembrane protein family and

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