Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-07-29
2008-12-30
Balasubram, Venkataraman (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S231500, C514S256000, C514S269000, C514S275000, C544S317000, C544S320000, C544S336000, C544S050000, C544S111000
Reexamination Certificate
active
07470681
ABSTRACT:
This invention features pyrimidine compounds of formula (I):R1iseach of R2and R4is H; R3is H, alkyl, aryl, heteroaryl, cyclyl, heterocyclyl, or alkylcarbonyl; R5is H or alkyl; n is 0, 1, 2, 3, 4, 5, or 6; X is NRc; Y is covalent bond, CH2, C(O), C═N—Rc, C═N—ORc, C═N—SRc, O, S, S(O), S(O2), or NRc; Z is N or CH; one of U and V is N, and the other is CRc; and W is O, S, S(O), S(O2), NRc, or NC(O)Rc; in which each of Raand Rb, independently, is H, alkyl, aryl, heteroaryl; and Rcis H, alkyl, aryl, heteroaryl, cyclyl, heterocyclyl, or alkylcarbonyl.
REFERENCES:
patent: 6384032 (2002-05-01), Ono et al.
patent: 6660733 (2003-12-01), Sun et al.
patent: 6680315 (2004-01-01), Ono et al.
patent: 6693097 (2004-02-01), Ono et al.
patent: 6706264 (2004-03-01), Leonard et al.
patent: 6858606 (2005-02-01), Sun et al.
patent: 6958332 (2005-10-01), Sun et al.
patent: 7045517 (2006-05-01), Ono et al.
patent: 7067514 (2006-06-01), Ono et al.
patent: 2005/0250787 (2005-11-01), Sun et al.
patent: 2005/0282809 (2005-12-01), Ono et al.
patent: 2006/0025409 (2006-02-01), Ono et al.
patent: WO 00/62778 (2000-10-01), None
European Search Report dated Feb. 7, 2005.
Trincheri, G., “Function and Clinical Use of Interleukin-12”, Current Opinion in Hematology, 4: 59-66, 1997.
Mylari, et al., Sorbitol Dehydrogenase Inhibitors (SDIs): A New Potent, Enantiometric SDI, 4- [2-1-R-Hydroxy-ethyl)-pyrimidin-4yl]-piperazine-1-sulfonic Acid Dimethylamide, J. Med. Chem., vol. 44, 2001, pp. 2695-2700.
Arvanitis et al., Non-Peptide Corticotropin-Releasing Hormone Antagonist: Syntheses and Structure-Activity Relationships of 2-Anilinopyrimidines and -triazines, J. Med. Chem., vol. 42, 1999, pp. 805-818.
International Search Report dated Jun. 12, 2003.
Nishigaki et al. “Synthesis of Iminodipyrimidnies”, Tetrahedron Letters. 7:539-542 (1969).
Becher, et al., “Experimental Autoimmune Encephalitis and Inflammation in the Absence of Interleukin-12,” The Journal of Clinical Investigation, vol. 110, No. 4, pp. 493-497 (2002).
Maeyama, et al., “Attenuation of Bleomycin-induced Pheumopathy in Mice by Monoclonal Antibody to Interleukin-12,” Am J Physiol, Lung Cell Mol. Physiol. vol. 280, pp. L1128-L1137 (2001).
Kostik Elena
Ono Mitsunori
Przewloka Teresa
Sun Lijun
Wada Yumiko
Balasubram Venkataraman
Edwards Angell Palmer & & Dodge LLP
Hsi Jeffrey D.
Russett Mark D.
Synta Pharmaceuticals Corp.
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