MALDI/LDI source

Details MALDI/LDI source MALDI/LDI source

2005-11-21

2008-12-02

Berman, Jack I (Department: 2881)

Radiant energy

Ionic separation or analysis

With sample supply means

C250S42300F, C250S3960ML, C250S281000, C250S42300F, C250S282000

Reexamination Certificate

active

07459676

ABSTRACT:
A MALDI/LDI source includes an ion collection device, e.g., a skimmer, orifice, mass analyzer, ion transfer optics and/or ion guide, configured for use with a short focal length lens with a large aperture. In some embodiments, the ion collection device includes an outer edge that can be disposed approximately parallel to a beam envelope between a lens and a focal point positioned at a MALDI/LDI sample. This configuration of the outer edge allows the ion collection device to be placed in close proximity to the focal point. This placement results in favorable collection efficiencies of laser desorbed analyte from the MALDI/LDI sample.

REFERENCES:
patent: 4720633 (1988-01-01), Nelson
patent: 5118937 (1992-06-01), Hillenkamp et al.
patent: 5663561 (1997-09-01), Franzen et al.
patent: 6110291 (2000-08-01), Haruta et al.
patent: 6646261 (2003-11-01), Krans
patent: 6680477 (2004-01-01), Beck et al.
patent: 7064318 (2006-06-01), Bui
patent: 7161159 (2007-01-01), Hill et al.
patent: 7180058 (2007-02-01), Izgarian
patent: 2002/0011560 (2002-01-01), Sheehan et al.
patent: 2004/0245453 (2004-12-01), Izgarian et al.
patent: 2006/0186332 (2006-08-01), Haase et al.
Spengler et al., “Scanning Microprobe Matrix-Assisted Laser Desorption Ionizion (SMALDI) Mass Spectrometry: Instrumentation for Sub-Micrometer Resolved LDI and MALDI Surface Analysis,” J. Am. Soc. Mass Spectrom., Elsevier Sciences Inc., p. 735-748, (2002).
Piyadasa et al., “Imaging MALDI with an Orthogonal TOF Mass Spectrometer,” 52nd ASMS Conference on Mass Spec and Allied Topics, (2004).
Bouschen et al., “Automated 3D-SMALDI imaging with a lateral resolution of 1um,” Inst. Inorganic and Analytical Chem., (2003).
Luxembourg et al., “High Spatial Resolution Mass Spectrometric Imaging of Peptide and Protein Distributions on a Surface,” Analytical Chemistry, vol. 76 ( No. 18), p. 5339-5344, (2004).
Bouschen et al, “SMALDI Imaging at 1 um Lateral Resolution,” 52nd ASMS Conference on Mass Spectrom and Allied Topics, (2004).
Ens et al, “Abstract—Molecular Imaging using an Orthogonal-Injection Time-of-Flight Mass Spectrometer with a Matrix-Assisted Laser Desorption Ionization Source,” (2004).
Chaurand et al., “MALDI-MS Imaging of Tissue Sections with a Resolution of 10 microns,” Vanderbuilt Univ., (2002).
Schriver et al., “High Resolution Imaging Mass Spectrometry: Characterization of Ion Yields and Laser Spot Sizes,” Vanderbilt Univ., (2003).

Affiliated with

Also associated with

Rating

MALDI/LDI source does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with MALDI/LDI source, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and MALDI/LDI source will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4026065