Method for the treatment of adult respiratory distress syndrome

Details Method for the treatment of adult respiratory distress syndrome Method for the treatment of adult respiratory distress syndrome

1985-04-02

1987-08-11

Foelak, Morton

Drug, bio-affecting and body treating compositions

Lymphokine

424101, 530387, 514921, A61K 3900

Patent

active

046861009

ABSTRACT:
A method for treating adult respiratory distress syndrome (ARDS) and sepsis in a patient in need thereof which comprises administering to said patient an antibody to complement component C5a or the des Arg derivative thereof in an amount effective to treat ARDS and sepsis.

REFERENCES:
Kraut et al, "Effects of CVF Treatment on Latent FeLV Infection", J. Virology, vol. 54(3), 1985, pp. 873-875.
Yancy et al, "Human C5a Modulates Moacytes Fe and C3 Receptor Expression", J. Immunol., vol. 135(1), 1985, pp. 465-470.
C.A. #176799b, vol. 103, 1986, Johnson et al.
C.A. #86170k, vol. 103, 1986, Lanier et al.
Craddock, P. R., et al., "Complement (C5a)-Induced Granulocyte Aggregation in Vitro: A Possible Mechanism of Complement-Mediated Leukostasis and Leukopenia," J. Clin. Invest. 60, 260-264 (Jul. 1977).
Duff, Patrick, "Pathophysiology and Management of Septic Shock," J. Reprod. Med. 24 (3), 109-117. (Mar. 1980).
Fein, A. M., et al., "The Risk Factors, Incidence, and Prognosis of ARDS following Septicemia," Chest 83 (1), 40-42 (Jan. 1983).
Fowler, A. A., et al., "Adult Respiratory Distress Syndrome: Risk with Common Predispositions," Ann. Int. Med. 98 (5), 593-597 (May 1983).
Gelfand, J. A., et al., "Alternative Complement Pathway Activation Increases Mortality in Model of Burn Injury in Mice," J. Clin. Invest. 70, 1170-1176 (Dec. 1982).
Hammerschmidt, D. E., et al., "Corticosteroids Inhibit Complement-Induced Granulocyte Aggregation: A Possible Mechanism for Their Efficacy in Shock States," J. Clin. Invest. 63, 798-803 (Apr. 1979).
Hammerschmidt, D. E., et al., "Association of Complement Activation and Elevated Plasma-C5a with Adult Respiratory Distress Syndrome," The Lancet, 947-949 (May 3, 1980).
Hammerschmidt, D. E., et al., "Granulocyte Aggregometry: A Sensitive Technique for the Detection of C5a and Complement Activation," Blood 55 (6), 898-902 (Jun. 1980).
Hosea, Steven, et al., "Role of Complement Activation in a Model of Adult Respiratory Distress Syndrome," J. Clin. Invest. 66, 375-382 (Aug. 1980).
Parrish, D. A., et al., "Pulmonary Response of Fifth Component of Complement-Sufficient and -Deficient Mice to Hyperoxia," J. Clin. Invest. 74, 956-965 (Sep. 1984).
Rinaldo, J. E. and Rogers, R. M., "Adult Respiratory Distress Syndrome," New England J. Med. 306, 900-909 (Apr. 15, 1982).
Sacks, Thomas, et al., "Oxygen Radicals Mediate Endothelial Cell Damage by Complement-Stimulated Granulocytes: An In Vitro Model of Immune Vascular Damage," J. Clin. Invest. 61, 1161-1167 (1977).
Stevens, J. H. and Raffin, T. A., "Adult Respiratory Distress Syndrome--I. Aetiology and Mechanisms," Post. Med. J. 60, 505-513 (Aug. 1984).
Stevens, J. H. and Raffin, T. A., "Adult Respiratory Distress Syndrome--II. Management," Post. Med. J. 60, 573-576 (Sep. 1984).
Tate, R. M. and Repine, J. E., "Neutrophils and the Adult Respiratory Distress Syndrome," Am. Rev. Respir. Dis. 128 (3), 552-559 (Sep. 1983).
Tonnesen, M. G., et al., "Neutrophil-Endothelial Cell Interactions: Modulation of Neutrophil Adhesiveness Induced by Complement Fragments C5a and C5a des arg and Formyl-Methionyl-Leucyl-Phenylalanine in Vitro," J. Clin. Invest. 74, 1581-1592 (Nov. 1984).
Weinberg, P. F., "Biologically Active Products of Complement and Acute Lung Injury in Patients with the Sepsis Syndrome," Am. Rev. Respir. Dis. 130, 791-796 (1984).

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