Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1998-07-07
1999-06-15
Degen, Nancy
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 74, 536 231, 536 2431, C07H 2104, C12Q 168
Patent
active
059121300
ABSTRACT:
The present invention provides a nucleic acid sequence which identifies and encodes a G protein gamma subunit (gpg) which was isolated from human pituitary gland. The invention provides for genetically engineered expression vectors and host cells comprising nucleic acid sequence encoding GPG and for gpg antisense molecules. The invention also provides for purified GPG; antibodies, antagonists and inhibitors which specifically bind GPG; and pharmaceutical compositions and methods of treatment based on GPG antagonists and inhibitors. The invention provides for diagnostic assays which utilize diagnostic compositions comprising nucleic acid sequences, or complements thereof, encoding GPG, purified GPG to be used as a positive control, and antibodies which specifically bind to GPG.
REFERENCES:
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Clapman et al., New Roles for G-protein .beta..gamma.-dimers in transmembrane signaling, Nature, 365:403-406, (1993).
Fisher et al., Characterization of the cDNA and Genomic Sequence of a G protein .gamma. Subunit (.gamma.5), Mol. Cell. Biol., 12:1585-91 (1992).
Iyengar, Molecular and functional diversity of mammalian G-stimulated adenylyl cyclases, FASEB Jour., 7:768-75, (1993).
Neer et al., Heterotrimeric G Proteins: Organizers of Transmembranes Signals, Cell, 80:249-257 (1995).
Stephens et al., A Novel Phosphoinositide 3 Kinase Activity in Myeloid-Derived Cells is Activated by G Protein .beta..gamma. Subunits, Cell, 77:83-93 (1994).
Watson et al., The G protein Linked Receptor Facts Book, pp. 350-355 (1994) .
Au-Young Janice
Guegler Karl J.
Murry Lynn E.
Seilhamer Jeffrey J.
Stuart Susan G.
Degen Nancy
Incyte Pharmaceuticals Inc.
Wang Andrew
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