Method for the production of...

Details Method for the production of... Method for the production of...

2003-07-31

2008-10-14

Shiao, Rei-tsang (Department: 1626)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

C549S075000, C549S076000

Reexamination Certificate

active

07435563

ABSTRACT:
The present invention relates to a process for the preparation of enantiomerically pure (S)-3-methyl-amino-1-(thien-2-yl)propan-1-ol of the formula II-Sby obtainment of (S)-3-hydroxy-3-thien-2-ylpropionitrile from its enantiomer mixture with the R isomer and the subsequent reaction of (S)-3-hydroxy-3-thien-2-ylpropionitrile with hydrogen and methylamine in the presence of a catalyst to give II-S.

REFERENCES:
patent: 5254737 (1993-10-01), Zimmerman
patent: 5491243 (1996-02-01), Berglund
patent: 0 273 658 (1988-07-01), None
patent: 0 457 559 (1991-11-01), None
patent: 0 650 965 (1994-10-01), None
Kamal et al. “Chemoenzymatic synthesis of duloxetine and its enantiomer: lipase-catalyzed resolution of 3-hydroxy-3-(2-thienyl) propanenitrile” Tetrahedron Letters, 2003, vol. 44, pp. 4783-4787.
Deeter et al. “Asymmetric Synthesis and Absolute Stereochemistry of LY248686” Tetrahedron Letters, 1990, vol. 31, pp. 7101-7104.
Pamies, O., Bäckvall, J.E. in Advanced Synthesis and Catalysis, vol. 343, No. 6-7, 2001, pp. 726-731.
Deeter, J. et al. in Tetrahedron Letters, vol. 31, No. 49, pp. 7101-7104, 1990.

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