Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...
Reexamination Certificate
2003-03-14
2008-08-19
Barnhart, Lora E (Department: 1651)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
C424S093700
Reexamination Certificate
active
07413897
ABSTRACT:
Hepatic progenitors comprise two populations of human hepatic stem cells, primitive and proximal hepatic stem cells, and two populations of committed progenitors, one for biliary cells and one for hepatocytes. Human primitive hepatic stem cells are a very small fraction of the liver cell population and give rise to proximal hepatic stem cells constituting a much larger fraction of the liver. Human proximal hepatic stem cells give rise to biliary and hepatocyte committed progenitors. Primitive and proximal stem cells are the primary stem cells for the human liver. Human primitive hepatic stem cells may be isolated by immunoselection from human livers or culturing human liver cells under conditions which select for a human primitive hepatic stem cell. Proximal hepatic stem cells may be isolated by immunoselection, or by culturing human liver cells under conditions which include a developmental factor. Proximal hepatic stem cells may also be isolated by culturing colonies comprising a primitive hepatic stem cell under conditions which include a developmental factor. Resulting compositions may be used for treating liver disorders and for producing bioartificial organs.
REFERENCES:
patent: 5576207 (1996-11-01), Reid et al.
patent: 5665589 (1997-09-01), Harris et al.
patent: 5789246 (1998-08-01), Reid et al.
patent: 5843633 (1998-12-01), Yin et al.
patent: WO 00/03001 (2000-01-01), None
patent: WO 02/29012 (2002-04-01), None
De Boer et al. Journal of Pathology. Jun. 1999. vol. 188, No. 2, pp. 21-206.
Berger et al. Blood. Nov. 1998. vol. 92, No. 10, Suppl.1, part 1-2, p. 567A.
Lemmer et al. Journal of Hepatology. 1998, vol. 29, pp. 450-454.
Roskams et al. Journal of Hepatology. 1998, vol. 29, pp. 455-463.
Fava et al. Journal of Clinical Oncology. Oct. 2001. vol. 19, No. 19, pp. 3951-3959.
Wang et al. Blood. Nov. 2001, vol. 98, No. 11, Part 1, p. 548.
Lowes et al. “Oval cell numbers in human chronic liver diseases are directly related to disease severity”. American Journal of Pathology. 1999, 154:537-541.
Suzuki A et al. 2002. Clonal identification and characterization of self-renewing pluripotent stem cells in the developing liver. J Cell Biol 156: 173-184.
Lewin, B, ed. “Oncogenes and cancer.” In: Genes VII (Oxford UK, Oxford University Press, 2000). pp. 875-876. QH430 .L487.
Shlomo Brill, et al., “Maturation-Dependent Changes in the Regulation of Liver-specific Gene Expression in Embryonal Versus Adult Primary Liver Cultures”, Differentiation, 1995, pp. 95-102, vol. 59.
Shlomo Brill, et al., “Expansion Conditions for Early Hepatic Progenitor Cells from Embryonal and Neonatal Rat Livers”, Digestive Diseases and Science, 1999, pp. 364-371, vol. 44, No. 2.
Orla M. Crosbie, et al., “In Vitro Evidence for the Presence of Hematopietic Stem Cells in the Adult Human Liver”, Hepatology, Apr. 1999, pp. vol. 29, No. 4.
Aleta R. Crawford, et al., “The Normal Adult human Liver Biopsy: A Quantitative Reference Standard”, Hepatology Aug. 1998, pp. 1193-1198, 323-331, vol. 28, No. 2.
Ira J. Fox, et al., “Treatment of the Crigler-Najjar Syndrome Type I with Hepatocyte Transplantation”, The New England Journal of Medicine, May 14, 1998, pp. 1422-1426, vol. 338, No. 20.
R. Gebhardt, et al., “Heterogeneous Expression of Glutamine Synthetase M RNA in Rat Liver Parenchyma Revealed by in Situ Hybridization and Northeren Blot Analysis of RNA from Periportal and Perivenous Hepatocytes”, Federation of Eurepean Biochemical Societies, Dec. 1988, pp. 89-93, vol. 241, No. 1,2.
J.W. Grisham, et al., “Liver Stem Cells”, Stem Cells, 1997, pp. 233-282.
Samuel H. Sigal, et al., “Characterization and Enrichment of Fetal Rat Hepatoblasts by Immunoadsorption(“Panning”) and Flurescence-Activated Cell Sorting” Hepatology, Apr. 1994, pp. 999-1006, vol. 19, No. 4.
Samuel H. Sigal, et al., “Evidence for terminal Differentiation Process in the Rat Liver” The Journal of the International Society of Differentiation, Jul. 1995, pp. 35-42, vol. 59, No. 1.
Neil D. Theise, et al., “The Canals of Hering and Hepatic Stem Cells in Humans” Hepatology, Dec. 1999, pp. 1425-1433, vol. 30, No. 6.
Peter G. Traber, et al., “Physiologic Significance and Regulation of Hepatocellular Heterogeneity” Gastroenterology, Oct. 1988, pp. 1130-1143, vol. 95, No. 4.
Ken Zaret, et al., “Developmental Competence of the Gut Endoderm Genetic Potentiation by GATA and HNF3/Fork Head Proteins”, Development Biology, May 1, 1999, pp. 1-10, vol. 209, No. 1.
Ken Zaret, et al, “Early Liver Differentiation: Genetic Potentiation and Multilevel Growth Control”, Current Opinion Genetics & Development, Oct. 1998, pp. 526-531, vol. 8, No. 5.
Isabel Zvibel, et al. “phenotypic Characterization of Rat Hepatoma Cell Lines and Lineage-Specific Regulation of Gene Expression by Differentiation Agents”, Differentiation, 1998, pp. 215-223, vol. 63.
Smith et al., “Appearance of Oval Cells in the Liver of Rats After Long-term Exposure to Ethanol,”Hepatology, Jan. 1996, pp. 145-154.
Schmelzer, E., et al., “Human hepatic stem cells from fetal and postnatal donors”, JEM, vol. 204, No. 8, pp. 1973-1987 (Aug. 6, 20007).
Schmelzer, E., et al., “Human hepatic stem cells from fetal and postnatal donors”, JEM Online Supplemental Materials, http://www.jem.org/cgi/content/full/jem.20061603/DC1 , pp. 1-17 (2007).
Tateno, Chise et al., “Growth potential and differentiation capacity of adult rat hepatocytes in vitro”,Wound Repair and Regeneration, 1999, vol. 7. No. 1, pp. 36-44.
Bruce Andrew T.
Furth Mark
Ludlow John W.
Moss Nicholas
Reid Lola M.
Barnhart Lora E
Foley & Lardner LLP
Talapatra Sunit
University of North Carolina at Chapel Hill
Vesta Therapeutics, Inc.
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