Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-05-18
2008-10-21
Shameem, Golam M (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S407000
Reexamination Certificate
active
07439263
ABSTRACT:
Compounds of formula (I):wherein:X1represents an atom or group selected from CR4aR4b, O, S(O)q1and NR5, wherein R4a, R4b, q1and R5are as defined in the description,m1represents zero or an integer from 1 to 4 inclusive,m2represents an integer from 1 to 4 inclusive,n1and n2, which may be identical or different, each represent an integer from 1 to 3 inclusive,R1represents hydrogen or a group selected from carboxy, alkoxycarbonyl, optionally substituted carbamoyl and optionally substituted alkyl,R2represents hydrogen or alkyl,Ak represents an optionally substituted alkylene chain,p represents zero, 1 or 2,R3represents hydrogen or cyano,X2and X3, which may be identical or different, each represent either S(O)q2, or CR6aR6b, wherein q2, R6aand R6bare as defined in the description,its optical isomers, where they exist, and its addition salts with a pharmaceutically acceptable acid.Medicinal products containing the same which are useful as DPP-IV inhibitors.
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Villhauer, et al.,J. Med. Chem., 2003, 46, 2774-2789.
Benoist Alain
Combettes Murielle
De Nanteuil Guillaume
Harley Elizabeth
Hueschen and Sage
Les Laboratoires Servier
Shameem Golam M
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