Estrogen receptor genes and utilization thereof

Details Estrogen receptor genes and utilization thereof Estrogen receptor genes and utilization thereof

2001-11-15

2008-10-07

Pak, Michael (Department: 1646)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S069700, C435S320100, C435S325000, C536S023500

Reexamination Certificate

active

07432078

ABSTRACT:
The present invention relates to an estrogen receptor gene, characterized by comprising a nucleotide sequence coding for any one of the following amino acid sequences:(a) the amino acid sequence of SEQ ID NO:1,(b) an amino acid sequence of a protein having an estrogen receptor activity, said amino acid sequence has at least 90% sequence identity with the amino acid sequence of SEQ ID NO:1,(c) an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO:2, and(d) an amino acid sequence of a protein having an estrogen receptor activity, said amino acid sequence is encoded by a nucleotide sequence having at least 90% sequence identity with a DNA having the nucleotide sequence of SEQ ID NO:2, and the like. The estrogen receptor gene and the like can be applied to assay systems for evaluating the ability of chemical substances to regulate the estrogen receptor activity.

REFERENCES:
patent: 2000-201688 (2000-07-01), None
patent: WO 99/11760 (1999-03-01), None
The EMBO Journal, 5(5), 891-897 (1986).
J. Steroid Biochem. Molec. Biol., 59(2), 135-145 (1996).
Nucleic Acids Research, 27(4), 919-929 (1999).
J. Steroid Biochem. Molec. Biol., 55(2), 261-269 (1995).
Toxicological Sciences, 52 326-339 (2000).

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