Process for producing 3-acylaminobenzofuran-2-carboxylic...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C549S467000

Reexamination Certificate

active

07439368

ABSTRACT:
The present invention provides a process of preparing a compound of the formula [I]:wherein X is a group of the formula: —N═ or —CH═; R1is a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a cyano group or an amino group optionally substituted by a lower alkyl group; Ring A is a nitrogen-containing heterocyclic group; Ring B is an optionally substituted benzene ring or an optionally substituted pyridine ring; and R3is a hydrogen atom or a lower alkyl group, or a pharmaceutically acceptable salt thereof, which is useful as an inhibitor of activated blood coagulation factor X.

REFERENCES:
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patent: WO-99/14191 (1999-03-01), None
patent: WO-02/085838 (2002-10-01), None
Djakovitch, L et al., Journal of Organometallic Chemistry, 1999, vol. 592, No. 2, pp. 225 to 234, p. 226, Scheme 1.
Ingold, K.U. et al., Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry, 1972-1999, (1986), No. 8, p. 1337-44.
Viti, G. et al., Journal of heterocyclic Chemistry, 1990, vol. 27, No. 5, p. 1369-75, p. 1369, Scheme 1.
Harrison, C.R. et al., Journal of Organic Chemistry, 1983, vol. 48, No. 21, p. 3721-8, p. 3727, left col. (b).
Cable, et al., “Synthesis of Carbon-14 Labelled NK-1 Receptor Antagonists GR203040 and GR205171”, Journal of Labelled Compounds and Radiopharmaceuticals, vol. 43, pp. 49-45, XP-002480616, 2000.

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