Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2003-09-15
2008-10-07
Shameem, Golam M (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S184000, C546S192000, C546S195000, C546S203000, C546S204000, C549S200000, C549S429000, C568S303000, C568S308000, C568S325000, C568S326000, C514S315000, C514S317000, C514S319000, C514S675000, C514S680000
Reexamination Certificate
active
07432284
ABSTRACT:
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, metastatic bone disease, Pagets disease, periodontal disease, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer, in particular of the breast, uterus and prostate.
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Morimoto, et al. --Journal of American Chem. Society, vol. 124, pp. 3806-3807, 2002.
Meng Dongfang
Parker Dann LeRoy
Ratcliffe Ronald W.
Wilkening Robert R.
Camara Valerie J.
Merck & Co. , Inc.
Shameem Golam M
Zhao Yong
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