Preparation of halohydrocarbyl phosphonic acid diesters

Details Preparation of halohydrocarbyl phosphonic acid diesters Preparation of halohydrocarbyl phosphonic acid diesters

2005-03-08

2008-10-14

Shiao, Rei-tsang (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus esters

Reexamination Certificate

active

07435841

ABSTRACT:
In a process for the production of halohydrocarbyl phosphonic acid diesters via a Michaelis-Arbuzov type reaction which results in high conversion and selectivity of product with ease of purification; the improvement comprises reacting hydrocarbyl halide with trihdydrocarbyl phosphite in a molar ratio of about 6:1 and in the presence of an effective amount of a polarity lowering additive.

REFERENCES:
patent: 2436141 (1948-02-01), Goebel
patent: 2899454 (1959-08-01), McBee et al.
patent: 3064031 (1962-11-01), Zimmerer
patent: 3242236 (1966-03-01), Moedritzer
patent: 3251907 (1966-05-01), Roy
patent: 3548040 (1970-12-01), Sorstokke et al.
patent: 3600435 (1971-08-01), Randall et al.
patent: 3691275 (1972-09-01), Benghiat
patent: 3700760 (1972-10-01), Benghiat
patent: 4268507 (1981-05-01), Nguyen Mong
patent: 4338440 (1982-07-01), Hawkins
patent: 4483705 (1984-11-01), Purdum
patent: 5177238 (1993-01-01), Carter et al.
patent: WO 96/15134 (1995-11-01), None
Ezquerra et al., Synthetic Communication, 1995, 25(2): 191-194.
Gobel et al. (Phosphorus, Sulfur, and Silicon 1992) 73 (1-4), 67-80).
Ezquerra et al. (Synthetic Communications 1995) 25 (2), 191-4).
R. Washchbusch, et al. (Laboratoire Heteroelements et Coordination, URA CNRS 1499, DCPH, Ecole Polytechnique, Palaiseau, France, Comptes Rendus de L'Academie des Sciences, Series 11 C: Chimle (1998), 1(1),49-52).
Burton, D. J., Flynn, R. M., J. Fluorine Chemistry 10 (1977) 329.
Waschbush R., Carran J., and Savignac, P., Tetrahedron 52 (1996) 14199.
Ii, et al., Diethyl Iododifluoromethylphosphonate: A New Synthetic Method and its Reaction With Alkynes, Synthesis 1996, vol. 5, pp. 606-608.

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