Ester derivatives and medical use thereof

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters

Reexamination Certificate

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C560S177000, C514S512000, C514S514000

Reexamination Certificate

active

07432392

ABSTRACT:
A therapeutic agent for hyperlipidemia which has no side effects on the liver unlike conventional MTP inhibitors and has excellent MTP inhibitory activity. Also, provided is an ester compound represented by the general formula (1):or a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 5683682 (1997-11-01), Betts
patent: 5827875 (1998-10-01), Dickson, Jr. et al.
patent: 5962440 (1999-10-01), Sulsky
patent: 6057339 (2000-05-01), Gregg
patent: 6121283 (2000-09-01), Chang et al.
patent: 6171599 (2001-01-01), Miyamoto et al.
patent: 6235730 (2001-05-01), Sato et al.
patent: 6288234 (2001-09-01), Griffin
patent: 6369075 (2002-04-01), Ruggeri et al.
patent: 6617325 (2003-09-01), Lehmann-Lintz et al.
patent: 6713489 (2004-03-01), Ruggeri et al.
patent: 6818644 (2004-11-01), Lehmann-Lintz et al.
patent: 6943185 (2005-09-01), Susilo et al.
patent: 2001/0007678 (2001-07-01), Baert
patent: 2002/0012706 (2002-01-01), Vladyka, Jr.
patent: 2002/0028943 (2002-03-01), Griffin
patent: 2002/0032238 (2002-03-01), Priepke et al.
patent: 2003/0044528 (2003-03-01), Tanno et al.
patent: 2003/0114442 (2003-06-01), Heckel et al.
patent: 2004/0058903 (2004-03-01), Takasugi et al.
patent: 2005/0075367 (2005-04-01), Hagiwara et al.
patent: 2006/0089392 (2006-04-01), Hagiwara et al.
patent: 2006/0153913 (2006-07-01), Yamane et al.
patent: 2 291 471 (1999-12-01), None
patent: 2 324 800 (2000-10-01), None
patent: 2 376 881 (2001-01-01), None
patent: 1099701 (2001-05-01), None
patent: 1 769 793 (2007-04-01), None
patent: 47-25189 (1972-10-01), None
patent: 57-206612 (1982-02-01), None
patent: 3-1288 (1991-01-01), None
patent: 3-28404 (1991-04-01), None
patent: 05-097672 (1993-04-01), None
patent: 08-208476 (1996-08-01), None
patent: 9-59159 (1997-03-01), None
patent: 9-309834 (1997-12-01), None
patent: 11-228569 (1999-08-01), None
patent: 11-509238 (1999-08-01), None
patent: 11-246404 (1999-09-01), None
patent: 2000-169395 (2000-06-01), None
patent: 2000-281561 (2000-10-01), None
patent: 2001-172180 (2001-06-01), None
patent: 2002-220345 (2002-08-01), None
patent: 2003-73261 (2003-03-01), None
patent: 2003-509505 (2003-03-01), None
patent: 2003-531099 (2003-10-01), None
patent: 2003-321424 (2003-11-01), None
patent: 2004-10575 (2004-01-01), None
patent: 2004-510763 (2004-04-01), None
patent: WO 96/40640 (1996-12-01), None
patent: WO 97/26240 (1997-07-01), None
patent: WO 97/43257 (1997-11-01), None
patent: WO 98/23593 (1998-06-01), None
patent: WO 98/47875 (1998-10-01), None
patent: WO 99/63929 (1999-12-01), None
patent: WO 00/5201 (2000-02-01), None
patent: WO 00/32582 (2000-06-01), None
patent: WO 00/37422 (2000-06-01), None
patent: WO 00/56726 (2000-09-01), None
patent: WO 01/00183 (2001-01-01), None
patent: WO 01/00184 (2001-01-01), None
patent: WO 01/00189 (2001-01-01), None
patent: WO 01/05762 (2001-01-01), None
patent: WO 01/12601 (2001-02-01), None
patent: WO 01/21604 (2001-03-01), None
patent: WO 01/47898 (2001-07-01), None
patent: WO 01/47899 (2001-07-01), None
patent: WO 01/53260 (2001-07-01), None
patent: WO 01/77077 (2001-10-01), None
patent: WO 01/97810 (2001-12-01), None
patent: WO 02/04403 (2002-01-01), None
patent: WO 02/20501 (2002-03-01), None
patent: WO 02/28835 (2002-04-01), None
patent: WO 02/042271 (2002-05-01), None
patent: WO 02/42291 (2002-05-01), None
patent: WO 02/051385 (2002-07-01), None
patent: WO 02/081460 (2002-10-01), None
patent: WO 02/098839 (2002-12-01), None
patent: WO 05/021486 (2005-03-01), None
patent: WO 06/043510 (2006-04-01), None
patent: WO 06/046623 (2006-05-01), None
Hagiwara et al., CAPLUS AN 2003:696857 (Feb. 28, 2003), 2 Pages Only.
Rx for Success, Lipid Levels—The Risk of Arteriosclerosis, Prudential Financial, 2002, 2 pages.
http://www.nhlbi.nih.gov/health/dci/Diseases/Cad/CAD—WhatIs.html.
Japan Tobacco Inc. Clinical Development.
http://cholesterol.about.com/od/treatments/a/mttpinhibitor.htm.
Aggarwal et al., BMC Cardiovascular Disorders, 2005, 5:30, pp. 1-8.
http://www.mayoclinic.com/health/arteriosclerosis-atherosclerosis/DS00525/DSECTION=8.
http://www.mayoclinic.com/health/obesity/DS00314/DSECTION=7.
Ksander et al., Diaminoindanes as Microsomal Triglyceride Transfer Protein Inhibitors, J. Med. Chem., vol. 44 (26), pp. 4677-4687 (2001).
Robl et al.,Novel Series of Highly Potent Benzimidazole-Based Microsomal Triglyceride Transfer Protein Inhibitors, J. Med. Chem., vol. 44 (6), pp. 851-856 (2001).
Wetterau et al., Purification and Characterization of Microsomal Triglyceride and Cholesteryl Ester Transfer Protein from Bovine Liver Microsomes, Chem. Phys. Lipids, vol. 38, pp. 205-222 (1985).
Anastasiou, Theordore J., et al., “Syntheses of aminosalicylate-based polyanhydride prodrugs: esters, amides, and azos,” Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) 42(2), 121-122 (2001).
Chiou, W.L. et al., Pharmaceutical Application of Solid Dispersion Systems, J. Pharm. Sci. 60 (1971) 1281-1302.
Fischer et al., Journal of the Chemical Society (B), Rates of Base-catalyzed Hydrolysis of Substituted Aryl Benzoates, 1971, pp. 1818-1819.
Shiomi et al., MTP inhibitor decreases plasma cholesterol levels in LDL receptor-deficient WHHL rabbits by lowering the VLDL secrection, European Journal of Pharmacology, vol. 431, pp. 127-131 (2001).
European Search Report of Application No. 04772363.0 dated Jan. 23, 2008.
International Search Report of PCT/JP03/02398 dated Jun. 3, 2003.
International Search Report of PCT/JP2004/012407 dated Feb. 15, 2005.
PCT International Search Report (PCT/JP2005/019744) dated Dec. 13, 2005.
International Search Report (PCT/JP2005/019041) dated Jan. 24, 2006.
SciFinder Scholar, version 2007.1; Chemical Abstracts Service, Columbus, OH; RN 339202-67-4 (accessed Feb. 6, 2008).
SciFinder Scholar, version 2007.1; Chemical Abstracts Service, Columbus, OH; RN 339202-91-4 (accessed Feb. 6, 2008).
SciFinder Scholar, version 2007.1; Chemical Abstracts Service, Columbus, OH; RN 516466-52-7 (accessed Feb. 6, 2008).
SciFinder Scholar, version 2007.1; Chemical Abstracts Service, Columbus, OH; RN 901355-00-8 (accessed Feb. 6, 2008).
SciFinder Scholar, version 2007.1; Chemical Abstracts Service, Columbus, OH; RN 888922-25-6 (accessed Feb. 6, 2008).
SciFinder Scholar, version 2007.1; Chemical Abstracts Service, Columbus, OH; RN 900909-90-2 (accessed Feb. 6, 2008).

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