SAK: modulation of cellular proliferation for treatment of...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving transferase

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

07413870

ABSTRACT:
The present invention relates to regulation of cellular proliferation. More particularly, the present invention is directed to nucleic acids encoding SAK, which is a protein kinase involved in modulation of cellular proliferation and cell cycle regulation. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions, antibodies, peptides, cyclic peptides, nucleic acids, RNAi, antisense nucleic acids, and ribozymes, that modulate cell cycle regulation and cellular proliferation via modulation of SAK; as well as to the use of expression profiles and compositions in diagnosis and therapy related to cell cycle regulation and modulation of cellular proliferation, e.g., for treatment of cancer and other diseases of cellular proliferation.

REFERENCES:
patent: 5589356 (1996-12-01), Tam
patent: 5650501 (1997-07-01), Dennis et al.
patent: 5959081 (1999-09-01), Lecka-Czernik
patent: 5976893 (1999-11-01), Dennis et al.
patent: 6569662 (2003-05-01), Tang et al.
patent: WO 01/53312 (2001-07-01), None
http://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=antisense
Kam et al., “Human SAK related to the PLK/polo family of cell cycle kinases shows high mRNA expression in testis,”Oncology Reports4: 505-510 (1997).
Chaturvedi et al., “Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway,”Oncogene18: 4047-4054 (1999).
Brown et al., “A human Cds 1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage,”Proc. Natl. Acad. Sci. USA96: 3745-3750 (1999).
Blasina et al., “A human homologue of the checkpoint kinase Cds 1 directly inhibits Cdc25 phosphatase,”Current Biology9: 1-10 (1998).
Hudson et al., “Late mitotic failure in mice lacking Sak, a polo-like kinase,”Current Biology11: 441-446 (2001).
Glover et al., “Polo-like kinases: a team that plays throughout mitosis,”Genes&Dev.12: 3777-3787 (1998).
Hudson et al., “Sak kinase gene structure and transcriptional regulation,”Gene241: 65-73 (2000).
Matsuoka et al., “Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase,”Science282: 1896-1897 (1998).
Fode, C., et al., “Sak, a murine protein-serine/threonine kinase that is related to theDrosophilapolo kinase and involved in cell proliferation,”Proc. Natl. Acad. Sci. USAJul. 1994, vol. 91, pp. 6388-6392.
Fode, Carol, et al., “Constitutive Expression of Murine Sak-a Suppresses Cell Growth and Induces Multinucleation,” Molecular and Cellular Biology, 1996, vol. 16, No. 9, pp. 4665-4672.
Hirao, Atsushi, et al. “DNA Damage-Induced Activation of p53 by the Checkpoint Kinase Chk2,” Science, 2000, vol. 287, pp. 1824-1827.
Karn, Thomas, et al., “Human SAK related to the PLK/polo family of cell cycle kinases shows high mRNA expression in testis,” Oncology Reports, 1997, vol. 4, pp. 505-510.
Lukas, Claudia, et al., “DNA Damage-activated Kinase Chk2 Is Independent of Proliferation or Differentiation Yet Correlates with Tissue Biology,” Cancer Research, 2001, vol. 61, pp. 4990-4993.
MacMillan, Jennifer C., et al., “Comparative Expression of the Mitotic Regulators SAK and PLK in Colorectal Cancer,” Annals of Surgical Oncology, vol. 8, No. 9, pp. 729-740, Oct. 2001.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

SAK: modulation of cellular proliferation for treatment of... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with SAK: modulation of cellular proliferation for treatment of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and SAK: modulation of cellular proliferation for treatment of... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4004935

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.