Use of morphogenetic proteins to treat human disc disease

Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Implantable prosthesis – Bone

Reexamination Certificate

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Reexamination Certificate

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07435260

ABSTRACT:
Bone morphogenetic proteins (BMPs) are introduced into an affected intervertebral disc without the inclusion of disc cells. The inventions applies to all known and yet-to-be developed or discovered BMPs, including BMP-1, -2, -3, -4, -5, -6, -7, -8, -9, -10, . . . BMPn. The BMP(s) may be obtained from natural and/or recombinant sources. The BMP(s) may be introduced using any surgical technique, including percutaneous or laparoscopic approaches. As one delivery mechanism, a passageway may be formed through the annulus, with the substances then being introduced through the passageway. Alternatively, a carrier may be sewn or otherwise adhered to the inside or outside of the existing annulus using standard surgical procedures. Additional therapeutic substances such as culture medium, growth factors, differentiation factors, hydrogels, polymers, antibiotics, anti-inflammatory medications, or immunosuppressive medications could be introduced in conjunction with the BMP(s).

REFERENCES:
patent: 2677369 (1954-05-01), Knowles
patent: 3366975 (1968-02-01), Pangman
patent: 3426364 (1969-02-01), Lumb
patent: 3551560 (1970-12-01), Thiele
patent: 3593342 (1971-07-01), Niebauer
patent: 3648294 (1972-03-01), Shahrestani
patent: 3855638 (1974-12-01), Pilliar
patent: 3867728 (1975-02-01), Substad et al.
patent: 3875595 (1975-04-01), Froning
patent: 3883902 (1975-05-01), Lynch
patent: 4229839 (1980-10-01), Schwemmer
patent: 4294753 (1981-10-01), Urist
patent: 4309777 (1982-01-01), Patil
patent: 4349921 (1982-09-01), Kuntz
patent: 4663358 (1987-05-01), Hyon et al.
patent: 4707872 (1987-11-01), Hessel
patent: 4714469 (1987-12-01), Kenna
patent: 4759766 (1988-07-01), Buettner-Janz et al.
patent: 4772287 (1988-09-01), Ray et al.
patent: 4801299 (1989-01-01), Brendel et al.
patent: 4863477 (1989-09-01), Monson
patent: 4874389 (1989-10-01), Downey
patent: 4904260 (1990-02-01), Ray et al.
patent: 4911718 (1990-03-01), Lee et al.
patent: 4917704 (1990-04-01), Frey et al.
patent: 4932969 (1990-06-01), Frey et al.
patent: 4946378 (1990-08-01), Hirayama et al.
patent: 5002576 (1991-03-01), Fuhrmann et al.
patent: 5047055 (1991-09-01), Bao et al.
patent: 5071437 (1991-12-01), Steffee
patent: 5108438 (1992-04-01), Stone
patent: 5123926 (1992-06-01), Pisharodi
patent: 5171280 (1992-12-01), Baumgartner
patent: 5171281 (1992-12-01), Parsons et al.
patent: 5192326 (1993-03-01), Bao et al.
patent: 5246458 (1993-09-01), Graham
patent: 5258031 (1993-11-01), Salib et al.
patent: 5258043 (1993-11-01), Stone
patent: 5314477 (1994-05-01), Marnay
patent: 5320644 (1994-06-01), Baumgartner
patent: 5370697 (1994-12-01), Baumgartner
patent: 5375823 (1994-12-01), Navas
patent: 5401269 (1995-03-01), Buttner-Janz et al.
patent: 5425773 (1995-06-01), Boyd et al.
patent: 5441508 (1995-08-01), Gazielly et al.
patent: 5458642 (1995-10-01), Beer et al.
patent: 5464439 (1995-11-01), Gendler
patent: 5507813 (1996-04-01), Dowd et al.
patent: 5514180 (1996-05-01), Heggeness et al.
patent: 5534028 (1996-07-01), Bao et al.
patent: 5534030 (1996-07-01), Navarro et al.
patent: 5545229 (1996-08-01), Parsons et al.
patent: 5556431 (1996-09-01), Buttner-Janz
patent: 5609635 (1997-03-01), Michelson
patent: 5645596 (1997-07-01), Kim et al.
patent: 5645597 (1997-07-01), Krapiva
patent: 5674294 (1997-10-01), Bainville et al.
patent: 5674296 (1997-10-01), Bryan et al.
patent: 5683465 (1997-11-01), Shinn et al.
patent: 5702450 (1997-12-01), Bisserie
patent: 5711960 (1998-01-01), Shikinami
patent: 5716416 (1998-02-01), Lin
patent: 5782830 (1998-07-01), Farris
patent: 5800549 (1998-09-01), Bao et al.
patent: 5824093 (1998-10-01), Ray et al.
patent: 5824094 (1998-10-01), Serhan et al.
patent: 5865845 (1999-02-01), Thalgott
patent: 5865846 (1999-02-01), Bryan et al.
patent: 5888226 (1999-03-01), Rogozinski
patent: 5893889 (1999-04-01), Harrington
patent: 5899941 (1999-05-01), Nishijima et al.
patent: 5928284 (1999-07-01), Mehdizadeh
patent: 5964807 (1999-10-01), Gan et al.
patent: 5972368 (1999-10-01), McKay
patent: 5976186 (1999-11-01), Bao et al.
patent: 5980504 (1999-11-01), Sharkey et al.
patent: 6022376 (2000-02-01), Assell et al.
patent: 6090112 (2000-07-01), Zucherman et al.
patent: 6110210 (2000-08-01), Norton et al.
patent: 6113639 (2000-09-01), Ray et al.
patent: 6132465 (2000-10-01), Ray et al.
patent: 6146420 (2000-11-01), McKay
patent: 6187048 (2001-02-01), Milner et al.
patent: 6224630 (2001-05-01), Bao et al.
patent: 6231615 (2001-05-01), Preissman
patent: 6245107 (2001-06-01), Ferree
patent: 6332779 (2001-12-01), Boyce et al.
patent: 6340369 (2002-01-01), Ferree
patent: 6344058 (2002-02-01), Ferree
patent: 6352557 (2002-03-01), Ferree
patent: 6371988 (2002-04-01), Pafford et al.
patent: 6419702 (2002-07-01), Ferree
patent: 6423095 (2002-07-01), Van Hoeck et al.
patent: 6428576 (2002-08-01), Haldimann
patent: 6454804 (2002-09-01), Ferree
patent: 6558390 (2003-05-01), Cragg
patent: 6620196 (2003-09-01), Trieu
patent: 6645247 (2003-11-01), Ferree
patent: 6648918 (2003-11-01), Ferree
patent: 6648919 (2003-11-01), Ferree
patent: 6648920 (2003-11-01), Ferree
patent: 6685695 (2004-02-01), Ferree
patent: 6755863 (2004-06-01), Ferree
patent: 6793677 (2004-09-01), Ferree
patent: 2001/0024823 (2001-09-01), Vulkicevic et al.
patent: 2002/0082697 (2002-06-01), Damien
patent: 2003/0100108 (2003-05-01), Altaman et al.
patent: 2003/0144197 (2003-07-01), Zheng et al.
patent: 2003/0212456 (2003-11-01), Lipschitz et al.
patent: 2003/0215426 (2003-11-01), French et al.
patent: 2003/0228292 (2003-12-01), Gazit et al.
patent: 2004/0054414 (2004-03-01), Trieu et al.
patent: 2004/0062753 (2004-04-01), Rezania et al.
patent: 2004/0064192 (2004-04-01), Bubb
patent: 2004/0220101 (2004-11-01), Ferree
patent: 2004/0220102 (2004-11-01), Ferree
patent: 2004/0230390 (2004-11-01), DiMauro et al.
patent: 2004/0236327 (2004-11-01), Paul et al.
patent: 2004/0236328 (2004-11-01), Paul et al.
patent: 2004/0244806 (2004-12-01), Ferree
patent: 2005/0119754 (2005-06-01), Trieu et al.
patent: 2008/0014179 (2008-01-01), Ferree
Carriers That Concentrate Native Bone Morpohogenetic Protein in Vivo K. De Groot, Ph.D. Tissue Engineering vol. 4, No. 4, 1998.
Carriers That Concentrate Native Bone Morphogenetic Protein in Vivo; K. De Groot, Ph.D Tissue Engineering vol. 4, Nov. 4, 1998.
Proceedings 14th Annual Meeting North American Spine Society, Oct. 1999.
Proceedings 13th Annual Meeting North American Spine Society, Oct. 1998.
S. Breit, S. Wahl; “TGF-β and Related Cytokines in Inflammation,” 2001.
S. Vukicevic, K. Sampath; “Bone Morphogenetic Proteins,” 2002.
S. Yoon, K. Kim, J. Li, J. Park, T. Akamaru, W. Elmer, W. Hutton; “The Effect of Bone Morphogenetic Protein-2 on Rat Intervertebral Disc Cells in Vitro,” SPINE, vol. 28, No. 16, pp. 1173-1780.
Padgett, et al.; “Human BMP Sequences Can Confer Normal Dorsal-Ventral Patterning in the Drosophilia Embryo,” Proc. Natl. Acad. Sci., 90, 2905-2909.
Paramore, C. et al.; “The Safety of OP-1 for Lumbar Fusion with Compression—a Canine Study,” Neurosurgery, vol. 44, No. 5, May 1999, pp. 1151-1155.
D. Kim, S. Moon, H. Kim, U. Kwon, M. Park, K. Han, S. Hahn, H. Lee, “Bone Morphogenetic Protein-2 Facilities Expression of Chondrogenic, not Osteogenic, Phenotype of Human Intervertebral Disc Cells,” SPINE, vol. 28, No. 24, pp. 2679-2684.
T. Gründer, C. Gaissmaier, J. Fritz, R. Stoop, P. Hortschansky, J. Mollenhauer, W. Aicher, “Bone morphogenetic protein (BMP)-2 enhances the expression of type II collagen and aggrecan in chondrocytes embedded in alginate beads,” OsteoArthritis and Cartilage, 2004, 12, pp. 559-567.
M. Kawakami, H. Hashizume, T. Matsumoto, Y. Enyo, M. Okada, M. Yoshida, Safety of Epidural Administration of Osteogenic Protein-1 (OP-1/BMP-7), SPINE, vol. 32, No. 13, pp. 1388-1393.
Masuda, Y. Imai, M. Okuma, C. Muehleman, K. Nakagawa, K. Akeda, E. Thonar, G. Andersson, H. An, “Osteogenic Protein-1 Injection into a Degenerated Disc Induces the Restoration of Disc Height and Structural Changes in the Rabbit Anular Punc

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