Substituted pyrazole derivatives and related compounds as...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

07432379

ABSTRACT:
Disclosed are compounds that are bradykinin B1receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B1receptor. Certain of the compounds exhibit increased potency and are also expected to exhibit increased duration of action.

REFERENCES:
patent: 3654275 (1972-04-01), McManus
patent: 5753629 (1998-05-01), Beria et al.
patent: 5916908 (1999-06-01), Giese et al.
patent: 6433185 (2002-08-01), Ferrari et al.
patent: 2002/0037856 (2002-03-01), Zhang et al.
patent: 2003/0119749 (2003-06-01), Zhang et al.
patent: 2003/0212113 (2003-11-01), Dyatkina et al.
patent: 2004/0063658 (2004-04-01), Roberts et al.
patent: 2004/0116353 (2004-06-01), Ferrari et al.
patent: 2004/0142997 (2004-07-01), Chen et al.
patent: 2005/0032868 (2005-02-01), Tung et al.
patent: 2005/0038099 (2005-02-01), Tung et al.
patent: 2006/0281733 (2006-12-01), Tung et al.
patent: 2007/0123531 (2007-05-01), Garofalo et al.
patent: 3421386 (1985-12-01), None
patent: 19854081 (2000-05-01), None
patent: 1304325 (2003-04-01), None
patent: 2310207 (1997-08-01), None
patent: 49100080 (1974-09-01), None
patent: 3-168743 (1991-07-01), None
patent: WO/96/05196 (1996-02-01), None
patent: WO98/11101 (1998-03-01), None
patent: WO/98/11101 (1998-03-01), None
patent: WO98/28268 (1998-07-01), None
patent: WO/99/27939 (1999-06-01), None
patent: WO00/31066 (2000-06-01), None
patent: WO/00/50418 (2000-08-01), None
patent: WO00/50418 (2000-08-01), None
patent: WO01/05783 (2001-01-01), None
patent: WO01/57034 (2001-08-01), None
patent: WO/01/87888 (2001-11-01), None
patent: WO01/87888 (2001-11-01), None
patent: WO/02/02523 (2002-01-01), None
patent: WO02/02523 (2002-01-01), None
patent: WO02/04424 (2002-01-01), None
patent: WO/02/08196 (2002-01-01), None
patent: WO/02/22655 (2002-03-01), None
patent: WO02/099388 (2002-12-01), None
patent: WO03/007945 (2003-01-01), None
patent: WO03/007958 (2003-01-01), None
patent: WO/03/015774 (2003-02-01), None
patent: WO03/015774 (2003-02-01), None
patent: WO/03/095429 (2003-11-01), None
patent: WO03/095429 (2003-11-01), None
patent: WO2004/033434 (2004-04-01), None
Baraldi et al. “Benzoyl Nitrogen Mustard Derivatives of Benzoheterocyclic Analogues of Netropsin: Synthesis and Biological Activity”Bioorganic&Medicinal Chemistry11:2381-2388 (2003).
Baraldi et al. “Synthesis and Antitumor Activity of New Benzoheterocyclic Derivatives of Distamycin A”J. Med. Chem.42:2675-2684 (2000).
Baraldi et al. “Novel Benzoyl Nitrogen Mustard Derivatives of Pyrazole Analogues of Distamycin A: Synthesis and Antileukemic Activity”Bioorganic&Medicinal Chemistry7:251-262 (1999).
Baraldi et al. “Structure-Activity Relationship of novel Tallimustine Derivatives: Synthesis and Antitumor Activity”Bioorganic&Medicinal Chemistry6(11):1247-1252.
Baraldi et al. “Synthesis and Antitumor Activity of Novel Distamycin Derivatives”Bioorganic&Medicinal Chemistry6(11):1241-1246 (1996).
Atwell et al. 5-Amino-1-(chloromethyl)-1,2-dihydro-3H-benz[e]indoles: Relationships between Structure and Cytotoxicity for Analogues Bearing Different DNA Minor Groove Binding SubunitsJ. Med. Chem.42:3400-3411 (1999).
Database CA Online XP002301180 Database Accession No. 1998:302076 Marchini et al. “Sequence-specific DNA alkylation of novel tallimustine derivatives”Anti-Cancer Drug Design13(3):193-205 (1998).
Database CA Online XP-002301181 Database Accession No. 1992:173857 Lee et al. “Pyrazole analogs of the dispyrrolecarboxamide anti-tumor antibiotics: Synthesis, DNA binding and anti-tumor properties”Anti-Cancer Drug Design6(5):501-517.
Database CA Online XP-002301226 Database Accession No. 1998:233560 Abdallah et al. “A convenient synthesis of 5-amino-4-(2-benzothiazolyl)pyrazoles”Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry36(12):1175-1177 (1997).
Abdallah, et al. “A convenient synthesis of 5-amino-4-(2-benzothiazolyl) pyrazoles”Indian J. of Chem.36B:1175-1177 (1997).
Eighandour, Ahmed “Hydrazonoyl Halides in Heterocyclic Chemistry: Synthesis of New Polyfunctionally Substituted Pyrazoles, Pyridazines and Pyrazolo [3,4-d]pyridazines”J. Chem.. Research(s) 358-359 (1993).
Ibrahim, et al. “Utility of Hydrazidoyl Chlorides: Synthesis of New Pyrazoles, Pyrazolo [3,4-d]pyridazines, Pyrazolo [4,5-b]pyridines and Pyrazolo [4,5-d]pyrimidine Derivatives”J. Indian Chem. Soc.69:378-380 (1992).
Lee, et al. “Pyrazole analogues of the bispyrrolecarboxamide anti-tumour antibiotics: synthesis, DNA binding and anti-tumour properties”Anti-Cancer Drug Design6:501-517 (1991).
J.G. Menke, et al., “Expression Cloning of a Human B1Bradykinin Receptor,”J. Biol. Chem., 269(34);21583-21586 (1994).
J. F. Hess, “Cloning and Pharmacological Characterization of a Human Bradykinin (BK-2) Receptor”Biochem.and, Biophys. Res. Commun., 184:260-268 (1992).
Burch et al., “Bradykinin Receptor Antagonists”,Med. Res. Reviews, 10(2):237-269 (1990).
Clark, W.G. “Kinins and the Peripheral Central Nervous Systems”, Handbook of Experimental Pharmacology, vol. XXV: Bradykinin, Kallidin, and Kallikrein. Erdo, E.G. (Ed.), 311-322 (1979).
Ammons, W.S., et al., “Effects of Intracardiac Bradykinin on T2-T5Medial Spinothalamic Cells”,American Journal of Physiology, 249, R145-152 (1985).
Costello, A.H. et al., “Suppression of Carageenan-Induced Hyperalgesia, Hyperthermia and Edema by a Bradykinin Antagonist”,European Journal of Pharmacology, 171:259-263 (1989).
Laneuville, et al., “Bradykinin Analogue Blocks Bradykinin-induced Inhibition of a Spinal Nociceptive Reflex in the Rat”,European Journal of Pharmacology, 137:281-285 (1987).
Steranka, et al., “Antinociceptive Effects of Bradykinin Antagonists”,European Journal of Pharmacology, 136:261-262 (1987).
Steranka, et al., “Bradykinin as a Pain Mediator: Receptors are Localized to Sensory Neurons, and Antagonists have Analgesic Actions”,Neurobiology, 85:3245-3249 (1987).
Whalley, et al., inNaunyn Schmiederberg's Arch. Pharmacol., 336:652-655 (1987).
Back, et al., “Determination of Components of the Kallikrein-Kinin System in the Cerebrospinal Fluid of Patients with Various Diseases”,Res. Clin.Stud. Headaches, 3:219-226 (1972).
Ness, et al., “Visceral pain: a Review of Experimental Studies”,Pain, 41:167-234 (1990).
Aasen, et al., “Plasma Kallikrein Activity and Prekallikrein Levels during Endotoxin Shock in Dogs”,Eur. Surg., 10:50-62(1977).
Aasen, et al., “Plasma Kallikrein-Kinin System in Septicemia”,Arch. Surg., 118:343-346 (1983).
Katori, et al., “Evidence for the Involvement of a Plasma Kallikrein/Kinin System in the Immediate Hypotension Produced by Endotoxin in Anaesthetized Rats”,Br. J. Pharmacol., 98:1383-1391 (1989).
Marceau, et al., “Pharmacology of Kinins: Their Relevance to Tissue Injury and Inflammation”,Gen. Pharmacol., 14:209-229 (1982).
Weipert, et al., “Attenuation of arterial blood pressure fall in endotoxin shock in the rat using the competitive bradykinin antagonist I vs-I vs-[Hyp2,Thi5,8DPhe7]-Bk (B4148)”Brit J Pharm94:282-284 (1988).
Haberland, “The Role of Kininogenases, Kinin Formation and Kininogenase Inhibitor in Post Traumatic Shock and Related Conditions”,Klinische Woochen-Schrift, 56:325-331 (1978).
Ellis, et al., “Inhibition of Bradykinin-and Kallikrein-Induced Cerebral Arteriolar Dilation by Specific Bradykinin Antagonist”,Stroke, 18:792-795 (1987).
Kamitani, et al., “Evidence for a Possible Role of the Brain Kallikrein-Kinin System in the Modulation of the Cerebral Circulation”,Circ. Res., 57:545-552 (1985).
Barnes, “Inflammatory Mediator Receptors and Asthma”,Am. Rev. Respir. Dis., 135:S26-S31 (1987).
Fuller, et al., 

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Substituted pyrazole derivatives and related compounds as... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted pyrazole derivatives and related compounds as..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted pyrazole derivatives and related compounds as... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4004243

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.