Immune modulator

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Testing efficacy or toxicity of a compound or composition

Reexamination Certificate

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Details

C424S009100, C424S093100, C424S093400, C424S184100, C424S234100, C424S278100, C424S282100, C435S243000, C435S252100, C435S253200

Reexamination Certificate

active

07413728

ABSTRACT:
Use of an immune modulator composition and/or pharmaceutical composition comprising a whole cell of a bacterium from the generaRhodococcus, Gordonia, Nocardia, Dietzia, TsukamurellaandNocardioides, for use in the manufacture of a medicament for the treatment of an autoimmune disease or autoimmune disorder, including certain vascular disorders.

REFERENCES:
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patent: 706122 (1999-06-01), None
patent: WO 85/05034 (1985-11-01), None
patent: WO 03/049752 (2003-06-01), None
patent: WO 2004/022093 (2004-03-01), None
Kunkel, H.G., “Part V, Immune Disease”, in, Cecil Textbook of Medicine, eds. Beeson, McDermott, & Whyngaarden, 15thedition, W.B. Saunders Company, Phila., PA, 1979pp. 126-163.
Conforti, Anita, et al., “Specific and long lasting suppression of rat adjuvant arthritis by low-doseMycobacterium butyricum,” European Journal of Pharmacology, vol. 324 No. 2-3 (1997) pp. 241-247.
Zuany-Amorim et al., “Long-Term Protective and Antigen-Specific Effect of Heat-KilledMycobacterium vaccaein a Murine Model of Allergic Pulmonary Inflammation,”The Journal of Immunology, 169: 1492-1499 (2002).
Stansby et al., “Prevention of Experimental Myointimal Hyperplasia by Immunomodulation,”Eur. J. Vasc. Endovasc. Surg., 23:23-28 (2002).
Haanen et al., “Selection of a Human T Helper Type 1-like T cell Subset by Mycobateria,”J. Exp. Med., 174: 583-592 (1991).
Stanford et al., “Immunotherapy with Mycobacterium Vaccae in the Treatment of Tuberculosis,”Frontiers in Bioscience, 9: 1701-1719 (2004).
Smit et al., “Therapeutic treatment with heat-killedMycobacterium vaccae(SRL172) in a mild and severe mouse model for allergic asthma,”European Journal of Pharmacology, 470: 193-199 (2003).

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