Immunogenic compositions including rough phenotype Brucella...

Details Immunogenic compositions including rough phenotype Brucella... Immunogenic compositions including rough phenotype Brucella...

2003-12-11

2008-08-26

Navarro, Mark (Department: 1645)

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

C435S320100, C536S023100

Reexamination Certificate

active

07416878

ABSTRACT:
Live attenuated vaccines against brucellosis and infection by other diseases are described. It has been discovered that trans complementation of theBrucellawboA gene can be used to maintain an expression vector in an attenuatedBrucellahost cell in a vaccinee. Further, heterologous antigens can be expressed using thisBrucellaplatform, thus effecting a multivalent vaccine againstBrucellaand the disease corresponding to the heterologous antigen.

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