Compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C544S279000

Reexamination Certificate

active

07423042

ABSTRACT:
This invention relates to a novel group of 8-Alkyl/Aryl-4-aryl-2-N-(alkylamino)-N″-substituted-N′-cyanoguanidino-8H-pyrido[2,3-d]pyrimidin-7-one compounds, processes for the preparation thereof, the use thereof in treating CSBP/p38 kinase mediated diseases and pharmaceutical compositions for use in such therapy.

REFERENCES:
patent: 3843663 (1974-10-01), Williams et al.
patent: 4560691 (1985-12-01), Lesher et al.
patent: 4886807 (1989-12-01), Kitamura et al.
patent: 4897395 (1990-01-01), Duch et al.
patent: 5304560 (1994-04-01), Shimazaki et al.
patent: 5409930 (1995-04-01), Spada et al.
patent: 5426110 (1995-06-01), Gossett et al.
patent: 5466692 (1995-11-01), Ellingboe
patent: 5547954 (1996-08-01), Henrie, II et al.
patent: 5597776 (1997-01-01), Bratz et al.
patent: 5620981 (1997-04-01), Blankley et al.
patent: 5733913 (1998-03-01), Blankley et al.
patent: 5733914 (1998-03-01), Blankley et al.
patent: 5760220 (1998-06-01), Giguere et al.
patent: 5767097 (1998-06-01), Tam
patent: 5817670 (1998-10-01), Takayama et al.
patent: 5945422 (1999-08-01), Doherty et al.
patent: 6083948 (2000-07-01), Wilde
patent: 6200977 (2001-03-01), Cusing et al.
patent: 6277989 (2001-08-01), Chakravarty et al.
patent: 6476031 (2002-11-01), Chakravarty et al.
patent: 6479463 (2002-11-01), Wang et al.
patent: 6492520 (2002-12-01), Chen
patent: 6498163 (2002-12-01), Boschelli et al.
patent: 6528508 (2003-03-01), Salituro et al.
patent: 6528513 (2003-03-01), Cusing et al.
patent: 6593333 (2003-07-01), Cumming
patent: 6800626 (2004-10-01), Salituro et al.
patent: 6809199 (2004-10-01), Doherty et al.
patent: 6838559 (2005-01-01), Vaccaro et al.
patent: 6875769 (2005-04-01), Chen
patent: 7235551 (2007-06-01), Adams et al.
patent: 2003/0114671 (2003-06-01), Chen
patent: 2004/0009993 (2004-01-01), Angiolini
patent: 2004/0063658 (2004-04-01), Roberts et al.
patent: 2004/0116697 (2004-06-01), Adams et al.
patent: 2004/0142945 (2004-07-01), Barbosa et al.
patent: 2004/0209901 (2004-10-01), Adams et al.
patent: 2004/0224958 (2004-11-01), Booth et al.
patent: 2004/0235847 (2004-11-01), Quan et al.
patent: 2004/0236084 (2004-11-01), Biwersi et al.
patent: 2004/0242604 (2004-12-01), Bhattacharya et al.
patent: 2005/0187217 (2005-08-01), Wilson et al.
patent: 2005/0203109 (2005-09-01), Adams et al.
patent: 2005/0272728 (2005-12-01), Altenbach et al.
patent: 2006/0235029 (2006-10-01), Callahan et al.
patent: 2006/0235030 (2006-10-01), Callahan et al.
patent: 2006/0258687 (2006-11-01), Boehm et al.
patent: 0 278 686 (1988-02-01), None
patent: 0 530 994 (1993-03-01), None
patent: 2 123 830 (1984-02-01), None
patent: 1-261306 (1989-10-01), None
patent: 20000038350 (2000-08-01), None
patent: 2003/127542 (2003-05-01), None
patent: 2004-203751 (2004-07-01), None
patent: WO 92/12154 (1992-07-01), None
patent: WO 94/19350 (1994-09-01), None
patent: WO 95/15952 (1995-06-01), None
patent: WO 95/19774 (1995-07-01), None
patent: WO 95/33750 (1995-12-01), None
patent: WO 97/38992 (1997-10-01), None
patent: WO 98/05661 (1998-02-01), None
patent: WO 98/08846 (1998-03-01), None
patent: WO 98/27098 (1998-06-01), None
patent: WO 98/33798 (1998-08-01), None
patent: WO 99/41253 (1999-08-01), None
patent: WO 99/61444 (1999-12-01), None
patent: WO 99/64400 (1999-12-01), None
patent: WO 00/23444 (2000-04-01), None
patent: WO 00/43374 (2000-07-01), None
patent: WO 01/19828 (2001-03-01), None
patent: WO 01/42243 (2001-06-01), None
patent: WO 01/55147 (2001-08-01), None
patent: WO 01/70741 (2001-09-01), None
patent: WO 02/058695 (2002-08-01), None
patent: WO 02/059083 (2002-08-01), None
patent: WO02/060869 (2002-08-01), None
patent: WO 02/102315 (2002-12-01), None
patent: WO 2005/014558 (2005-02-01), None
Disorders Index of the National Institute of Neurological Disorders and Stroke, http://www.ninds.nih.gov/disorders/disorder—index.htm?css=print (NINDS Index).
Hashimoto, et al., J. of Pharmacol. and Experi. Therap., vol. 293, No. 2, pp. 370-375, 2000.
Hensley, et al., J. of Neurochem., vol. No. 5, 1999, pp. 2053-2058.
Johnson, et al., Science, vol. 298, Dec. 6, 2002, 1911-1912.
Kanda, et al., Brit. J. PHarmacol, vol. 132 (8), 2001, 1657-1664.
, Et al., Chin. Med. J. 2006, 119 (13): 1088-1093.
U.S. Appl. No. 11/613,517, filed Dec. 20, 2006, Adams, et al.
U.S. Appl. No. 11/613,598, filed Dec. 20, 2006, Adams, et al.
U.S. Appl. No. 11/871,039, filed Oct. 11, 2007, Adams, et al.
U.S. Appl. No. 11/839,830, filed Aug. 16, 2007, Adams, et al.
U.S. Appl. No. 11/839,833, filed Aug. 16, 2007, Adams, et al.
U.S. Appl. No. 11/839,834, filed Aug. 16, 2007, Adams, et al.
U.S. Appl. No. 11/908,435, filed Sep. 12, 2007, Callahan, et al.
U.S. Appl. No. 11/908,440, filed Sep. 12, 2007, Callahan, et al.
U.S. Appl. No. 11/908,839, filed Sep. 17, 2007, Callahan, et al.
U.S. Appl. No. 11/908,340, filed Sep. 11, 2007, Boehm, et al.
Adams et al., Progress in Medicinal Chemistry, vol. 38, pp. 2-61 (2001).
Armarego, W., Chem. Soc., Quinazolines, Part IV (JCSOA9) p. 561 (1962).
Boehm et al., J. Med. Chem. vol. 39, pp. 3929-3937 (1996).
Votta et al., Bone, vol. 15 (5) pp. 533-538 (1994).
Bradlerova et al., Chem. Zvesti, vol. 29 (6), pp. 795-802 (1975).
de Silva et al., J. Chem. Soc., vol. 4, pp. 685-690 (1995).
Engel & Steglich, Liebigs Ann. Chem., p. 1916 (1978).
Ferles et al., Collect. Czech. Chem. Commun., vol. 5 (46), pp. 1167-1172 (1981).
Fischer et al., Rec. Trav. Chim. Pays. Bas., vol. 84, p. 439 (1965).
Fulmer et al., J. Heterocycl. Chem., vol. 17 (4), pp. 799-800 (1980).
Gilbert, E., Synthesis, pp. 30-32 (1972).
Han et al., Science, vol. 265, pp. 808-811 (1994).
Hunter et al., Academic Press, San Diego, vol. 200, p. 3 (1991).
Irwin et al., Archives of Internal Medicine, vol. 157 (17), pp. 1981-1987 (1997).
Ishibashi et al., Chem. Pharm. Bull., vol. 37(8), pp. 2214-2216 (1989).
Johnson et al., PG.A., J.Chem.Soc., Perkin Trans., vol. 1, pp. 895-905 (1996).
Jurkowska-Kowalczyk, R., Chem., vol. 51 (6), pp. 1191-1199 (1977).
Katritzky et al., Synthesis, pp. 45-47 (Jan. 1993).
Kawasaki et al., J. Bio. Chem., vol. 272(30), pp. 18518-18521 (1997).
Mikailu et al., Zh. Obshch. Khim., vol. 56 (7), pp. 1513-1517 (1986).
Morton et al., Tetrahedron Letters, p. 4123 (1982).
Protecting Groups in Organic Synthesis, 2ndEdition, Greene TW and Wuts PSM, Wiley-Interscience, New York, pp. 10-174 (Hydroxyl and Phenolic) and pp. 309-403 (NH protection) (1991).
Santilli et al., J. Heterocycl Chem., vol. 8, pp. 445-453 (1971).
Snieckus, V., Tetrahedron Letters, vol. 29, p. 2135 (1988).
Stille et al., J. Amer. Chem. Soc., vol. 109, p. 5478 (1978).
Strzybny et al., J. Org. Chem., vol. 28, p. 3381 (1963).
Terashimia et al., M., Chem. Pharm. Bull., vol. 11, p. 4755 (1985).
Thompson et al., J. Org. Chem., vol. 49, p. 5237 (1984).
Uno et al., Bull. Chem. Soc. Japan., vol. 69, pp. 1763-1767 (1996).
Vartanyan et al., vol. 40, (9), pp. 552-560 (1987).
Borrel, et al., Coll. Czech. Chem. Commun., 1996, 61(6) pp. 901-909.
Baker et al., J. Heterocyclic Chem., 1964, vol. 1, pp. 263-270.
Anderson et al., J. Org. Chem., 1977, vol. 42, p. 993.
Victory et al., Heterocycles, 1985, 23(5), pp. 1135-1141.
Gallagher et al., Bioorganic and Med Chem, vol. 5(1), pp. 49-64 (1997).
Garigipati, R., Tetrahedron Letters, vol. 31,p. 190 (1989).
Kumada et al., Tetrahedron Letters, vol. 22, p. 5319 (1981).
Lamartina et al., Boll. Chim. Farm., vol. 129 (12), pp. 314-316 (1990).
Victory et al., Heterocycles, 1985, 23(8), pp. 1947-1950.
Victory et al., AFINIDAD, Mar. 1989, vol. 46, pp. 107-113 (Spanish).
Victory et al., J. Heterocycl. Chem, 1988, vol. 25, pp. 245-247.
Klotzer et al., Monatsh Chem., 1965, vol. 96, p. 1567.
Nishikawa et al., Chemical Pharm. Bull., 1976, vol. 24(9), pp. 2057-2077.
Carboni et al.,Gazzetta Chimica Italiana, vol. 97(8) pp. 1262-1273 (1967).
Carboni et al.,Gazzetta Chimica Italiana, vol. 98(10) pp. 1174-1188 (1968).
Ferrarini et al.,Journal of Heterocyclic Chemistry, vol. 21(2) pp. 417-419 (1984).
Ferrarini et al.,Journal of Heterocyclic Chemistry, vol. 34(5) pp. 1501-1510 (1997).
Rewcastle et al., Journal of Medicinal Chemistry, 1996 39(6), pp. 1823-1835.
Zavyalov, et

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