Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2001-11-02
2008-09-16
Myers, Carla (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S004000, C436S501000, C436S063000, C436S086000
Reexamination Certificate
active
07425419
ABSTRACT:
The present invention relates to a method of predicting pre-eclampsia (PE). The present invention also relates to a diagnostic kit for performing a method of predicting PE. In particular, the method determining the level of two or more markers selected from placenta growth factor (PIGF), plasminogen activator inhibitor-1 (PAI-1) plasminogen activator inhibitor-2 (PAI-2) and leptin.
REFERENCES:
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Levine et al. JAMA. 2005. 293: 77-85.
Reith A et al: “Plasminogen activator inhibitors (PAI-1 and PAI-2) in normal pregnancies, pre-eclampsia and hydatidiform mole.” British Journal of Obstetrics and Gynaecology, vol. 100, No. 4, 1993, pp. 370-374, XP008005703, ISSN: 0306-5456.
Estelles A et al: “Changes In The Plasma Levels Of Type 1 And Type 2 Plasminogen Activator Inhibitors In Normal Pregnancy And In Patients With Severe Preeclampsia” Blood, vol. 74, No. 4, 1989, pp. 1332-1338, XP008005702. ISSN: 0006-4971.
Torry D S et al: “Preeclampsia is associated with reduced serum levels of placenta growth factor.” American Journal of Obstetrics and Gynecology. Dec. 1998, vol. 179, No. 6 Pt 1, pp. 1539-1544, XP008005713, ISSN: 0002-9378.
Anim-Nyame N et al: “Longitudinal analysis of maternal plasma leptin concentrations during normal pregnancy and pre-eclampsia.” Human Reproduction Sep. 2000, vol. 15, No. 9, pp. 2033-2036, XP008005712, ISSN: 0268-1161.
Teppa R J et al: “Free leptin is increased in normal pregnancy and further increased in preeclampsia.”Metabolism: Clinical and Experimental. Aug. 2000, vol. 49, No. 8, pp. 1043-1048, XP008005711, ISSN: 0026-0495.
Chappell Lucy Charlotte
Hunt Beverley Jane
Poston Lucilla
Seed Paul Townsend
Banner & Witcoff , Ltd.
King's College London
Myers Carla
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