Apparatus for growing cells under variable hydrostatic...

Chemistry: molecular biology and microbiology – Apparatus – Bioreactor

Reexamination Certificate

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C435S325000, C435S283100, C435S304100, C435S305100

Reexamination Certificate

active

07422893

ABSTRACT:
An apparatus for growing cells in a 2-D cell cassette having a matrix for cell growth under pressure comprising two side assemblies which include a frame with a rigid support that fits over the 2-D cell cassette, with said assemblies positioned on either side of the cassette over the solid support sides, and a means to secure the sides of the cassette. The invention also provides different uses of this apparatus.

REFERENCES:
patent: 4833089 (1989-05-01), Kojima et al.
patent: 4851354 (1989-07-01), Winston et al.
Ute Hansen, Michael Schumke, Christian Domm, Niki Ioannidis, Joachim Hassenpflug, Thorsten Gehrke, Bodo Kurz. “Combination of reduced oxygen tension and intermittent hydrostatic pressure: a useful tool in articular cartilage tissue engineering,” Journal of Biomechanics 34, 941-949 (2001) . [Exhibit 1].
Cornelia Hasel, Susanne Durr, Silke Bruderlein, Ingo Melzner, Peter Moller. “A cell-culture system for long-term maintenance of elevated hydrostatic pressure with the option of additional tension,” Journal of Biomechanics 35, 579-584 (2002) . [Exhibit 2].
Jenneke Klein-Nulend, Jan Roelofsen, Cornelis M. Semeins, Antonius L.J.J. Bronkers, and Elisabeth H. Burger. “Mechanical Stimulation of Osteopontin mRNA Expression and Synthesis in Bone Cell Cultures,” Journal of Cellular Physiology 170, 174-181 (1997) . [Exhibit 3].
Thomas D. Brown. “Techniques for mechanical stimulation of cells in vitro: a review,” Journal of Biomechanics 33, 3-14 (2000) . [Exhibit 4].
Salwen SA, Szarowski DH, Turner JN, Bizios R. “Three-dimensional changes of the cytoskeleton of vascular endothelial cells exposed to sustained hydrostatic pressure,” Medical and Biological Engineering and Computing, 36(4), 520-527 (1998) . [Exhibit 5].
Nagatomi J, Arulanandam BP, Metzger DW, Meuniera, Bizios R. “Frequency- and duration-dependent effects of cyclic pressure on select bone cell functions,” Tissue Engineering, 7(6), 717-728 (2001) . [Exhibit 6].
Mitchell SB, Sanders JE, Garbini JL, Schuessler PK. “A device to apply user-specified strains to biomaterials in culture,” IEEE Trans Biomed Eng 48 (2), 268-273, (2001). [Exhibit 7].
Ozawa H, Imamura K, Abe E, Takahashi N, Hiraide T, Shibasaki Y, Fukuhara T, Suda T. “Effect of a continuously applied compressive pressure on mouse osteoblast-like cells (MC3T3-E1) in vitro,” Journal of Cellular Physiology, 142(1), 177-185 (1990). [Exhibit 8].
Saito S, Ngan P, Rosol T, Saito M, Shimizu H, Shinjo N, Shanfeld J, Davidovitch Z. “Involvement of PGE synthesis in the effect of intermittent pressure and Interleukin-1 β on bone resorption,” J Dent Res Jan, 70(1), 27-33 (1990). [Exhibit 9].
Takano-Yamamoto T, Soma S, Nakagawa K, Kobayashi Y, Kawakami M, Sukuda M. “Comparison of the effects of hydrostatic compressive force on glycosaminoglycan synthesis and proliferation in rabbit chondrocytes from mandiblar condylar cartilage, nasal septum, and spheno-occipital synchondrosis in vitro,” Am J Orthod Dentofacial Orthop, 99(5), 448-55 (1991). [Exhibit 10].
Koyama S, Miwa T, Sato T, Aizawa M. “Optical chamber system designed for microscopic observation of living cells under extremely high hydrostatic pressure,” Extremophiles Dec, 5(6), 409-15, (2001), [Exhibit 11].
Kaarniranta K, Elo MA, Sironen RK, Karjalainen HM, Helminen HJ, Lammi MJ. “Stress responses of mammalian cells to high hydrostatic pressure,” Biorheology 40, 87-92 (2003). [Exhibit 12].
Tezel J G, Wax MB. “Increased production of tumor necrosis factor-alpha by glial cells exposed to simulated ischemia or elevated hydrostatic pressure induces apoptosis in cocultured retinal ganglion cells,” The Journal of Neuroscience. 20(23), 8693-700, Dec. 1, 2000. [Exhibit 13].
Nerucci F, Fioravanti A, Cicero MR, Marcolongo K, SpiHaset C, Durr S, Bruderlein S, Melzner I, Moller P. “Preparation of a pressurization system to study the effect off a hydrostatic pressure on chondrocyte cultures,” In Vitro Cellular & Developmental Biology. Animal 34: Jan. 9-10, 1998. [Exhibit 14].
Wax Mb, Tezet G, Kobayashi S, Hernandez MR. “Responses of different cell lines from ocular tissues to elevated hydrostatic pressure,” Br J Ophthalmol 84, 423-428 (2000). [Exhibit 15].
Saris DB, Sanyal A, An KN, Fitzsimmons JS, O'Driscoll SW. “Periosteum responds to dynamic fluid pressure by proliferating in vitro,” Journal of Orthopaedic Research 17(5), 668-677 (1999). [Exhibit 16].
Suh JK, Baek GH, Aroen A, Malin CM, Niyibizi C, Evans CH, Westerhausen-Larson A. “Intermittent sub-ambient interstitial hydrostatic pressure as a potential mechanical stimulator for chondrocyte metabolism,” Osteoarthritis Cartilag, 7(1) :71-80 (1999). [Exhibit 17].
Carver SE, Heath CA. “Semi-continuous perfusion system for delivering intermittent physiological pressure to regenerating cartilage,” Tissue Engineering 5(1), 1-11 (1999). [Exhibit 18].
Hartig M, UIrich J, Haas-Peter Wiesmann. “Capacitively coupled electric fields accelerate proliferation of osteoblast-like primary cells and increase bone extracellular matrix formation in vitro,” Eur. Biophys J 29, 499-506 (2000). [Exhibit 19].
Brighton CT, Wang W, Seldes R, Zhang G. and Pollack S. “Signal Transduction in Electrically Stimulated Bone Cells,” JBJS 83 A (10): 1514-23, (2001). [Exhibit 20].
Hiroyuki Ozawa, Etsuko Abe, Yoshinobu Shibasaki, Tatsuo Fukuhara, and Tatsuo Suda. “Electric Fields Stimulate DNA Synthesis of Mouse Osteoblast-Like Cells (MC3T3-E1) by a Mechanism Involving Calcium Ions,” Journal of Cellular Physiology 138:477-483 (1989). [Exhibit 21].
Peter F. Armstrong, Carl T. Brighton, and Andrew M. Star. “Capacitively Coupled Electrical Stimulation of Bovine Growth Plate Chondrocytes Grown in Pellet Form,” Journal Orthopaedic Research 6:265-271, (1988). [Exhibit 22].
Gunter Fuhr, Henning Glasser, Torsten Muller, Thomas Schnelle. “Cell manipulation and cultivation under a.c. electric field influence in highly conductive culture media,” Biochimica et Biophysica Acta 1201, 353-360 (1994) [Exhibit 23].
Carl T. Brighton, M.D., PH.D., Enyi Okereke, M.D., Solomon R. Pollack, PH.D., Charles C. Clark, PH.D. “In Vitro Bone-Cell Response to a Capacitively Coupled Electrical Field,” Clinical Orthopaedics and Related Research. No. 285, 255-62 (1992). [Exhibit 24].
Korenstein R. Somjen D. Fischler H. Binderman I. “Capacitative pulsed electric stimulation of bone cells induction of cyclic amp changes and DNA synthesis,” Biochimica et Biophysica Acta. 803(4):302-7 (1984). [Exhibit 25].
Karen M. Haberstroh, Martin Kaefer, Natacha DePaola, Sarah A. Frommer, Rena Bizios. A Novel In-Vitro System for the Simultaneous Exposure of Bladder Smooth Muscle Cells to Mechanical Strain and Sustained Hydrostatic Pressure, Journal of Biomechanical Engineering 124, 208-213 (2002). [Exhibit 1].
U.S. Appl. No. 11/018,094, field Dec. 20, 2004, DiResta et al.
Office Action for Diresta et al., “Apparatus for growing cells under variable hydrostatic pressures”, U.S. Appl. No. 11/018,094, filed Dec. 20, 2004, dated Oct. 10, 2007.

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