Pyridine substituted furan derivatives as Raf kinase inhibitors

Details Pyridine substituted furan derivatives as Raf kinase inhibitors Pyridine substituted furan derivatives as Raf kinase inhibitors

2002-09-05

2008-05-20

Dentz, Bernard (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S318000, C514S326000, C544S152000, C546S194000, C546S283400

Reexamination Certificate

active

07375105

ABSTRACT:
Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy. Wherein X is O, CH2CO, S or NH, or the moiety X—R1is hydrogen; Y1and Y2independently represent CH or N; Ar is a mono- or fused bicyclic aromatic or heteroaromatic group which may be optionally substituted; one of X1and X2is selected from O, S or NR11and the other is CH, wherein R11is hydrogen, C1-6alkyl, aryl or arylC1-6alkyl.

REFERENCES:
patent: 4735958 (1988-04-01), Roth et al.
patent: 5776954 (1998-07-01), De Laszlo et al.
patent: 5792778 (1998-08-01), De Laszlo et al.
patent: WO 99/32455 (1999-07-01), None
patent: WO 01/34149 (2001-05-01), None
patent: WO 01/34150 (2001-05-01), None
patent: WO 01/38324 (2001-05-01), None
patent: WO 01/87877 (2001-11-01), None
Wermuth, C.G. (ed.), “Chapter 13: Molecular Variations Based on Isosteric Replacements”,The Practice of Medicinal Chemistry, pp. 204-237, Academic Press Ltd., Copyright (1996), XP-002190259.

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