Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2001-11-15
2008-09-02
Pak, Michael (Department: 1646)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S320100, C435S325000, C536S023500
Reexamination Certificate
active
07419800
ABSTRACT:
The present invention relates to an estrogen receptor gene, characterized by comprising a nucleotide sequence coding for any one of the following amino acid sequences:(a) the amino acid sequence of SEQ ID NO:1,(b) an amino acid sequence of a protein having an estrogen receptor activity, said amino acid sequence has at least 85% sequence identity with the amino acid sequence of SEQ ID NO:1,(c) an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO:2, and(d) an amino acid sequence of a protein having an estrogen receptor activity, said amino acid sequence is encoded by a nucleotide sequence having at least 85% sequence identity with a DNA having the nucleotide sequence of SEQ ID NO:2,and the like. The estrogen receptor gene and the like can be applied to assay systems for evaluating the ability of chemical substances to regulate the estrogen receptor activity.
REFERENCES:
patent: 2000-201688 (2000-07-01), None
patent: WO 99/11760 (1999-03-01), None
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Vidal, et al., “Survey and summary: Yeast forward and reverse ‘n’-hybrid systems”,Nucleic Acids Research, vol. 27, No. 4, pp. 919 to 929 (1999).
Young, et al., “Reptilian Sex Steroid Receptors: Amplification, Sequence and Expression Analysis”,J. Steroid Biochel. Molec. Biol., vol. 55, No. 2, pp. 261-269 (1995).
Matthews, et al., “Differential Binding Affinities of PCBs, HO-PCBs, and Aroclors with Recombinant Human, Rainbow Trout (Onchorhynkiss mykiss), and Green Anole (Anolis carolinensis) Estrogen Receptors, Using a Semi-High Throughput Competitive Binding Assay”,Toxicological Sciences, vol. 53, pp. 326-339 (2000).
Pak Michael
Panitch Schwarze Belisario & Nadel LLP
Sumitomo Chemical Company Limited
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