Process of preparing tetraamino intermediates

Details Process of preparing tetraamino intermediates Process of preparing tetraamino intermediates

1993-02-16

1994-07-12

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

560158, 564138, 564141, C07C20950

Patent

active

053290488

ABSTRACT:
This invention relates to bis-naphthalimides, including 2,2'-[1,2-ethanediylbis[imino(1-methy1-2,1-ethanediyl)]]-bis[5-nitro-1H-be nz[de]isoquinoline-1,3(2H)-dione] and 2,2'-[1,2-ethanediylbis[imino(2-methyl-2,1-ethanediyl)]]-bis[5-nitro-1H-be nz[de]isoquinoline-1,3(2H)-dione], processes for their preparation, pharmaceutical compositions containing them, and methods of using them to treat cancer in mammals.

REFERENCES:
patent: 4146720 (1979-03-01), Roldan et al.
patent: 4665071 (1987-05-01), Zee-Cheng et al.
patent: 4841052 (1989-06-01), Harnisch et al.
patent: 4874863 (1989-10-01), Brana et al.
patent: 4919848 (1990-04-01), Harnisch
Complexes with Asymmetric Tetramine Ligands, Part 1., Muir et al., Synth. React. Inorg. Met.-Org. Chem., 11(4), 317-331 (1981).
Stereochemistry of Complexes of Multidentate Ligands. Part 1. Asperger, et al., Inorganic Chemistry, vol. 4, No. 10, Oct. 1965.

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