Process for the preparation of tricyclo-[3.3.1.1.sup.3,7 ]dec-2-

Details Process for the preparation of tricyclo-[3.3.1.1.sup.3,7 ]dec-2- Process for the preparation of tricyclo-[3.3.1.1.sup.3,7 ]dec-2-

1992-10-26

1994-07-12

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

560169, C07D20926, C07C27120

Patent

active

053290135

ABSTRACT:
The present invention provides a process for the preparation of tricyclo- [3.3.1.1.sup.3,7 ]dec-2-yl-[R-(R*,R*)]-3-(1H-indol-3-ylmethyl)-3-methyl-4,9-dioxo-7,11-diph enyl-10-oxa-2,5,8-triazaundecanate, an important compound in the preparation of a new class of cholecystokinin inhibitors, wherein N-[(benzyloxy)carbonyl]-(R)-.beta.-amino-1-azido-2-phenylethane is hydrogenated, and subsequently, by means of carbon dioxide, the resulting N.sup..beta. -[(benzyloxy)-carbonyl]-(R)-.beta.-amino-2-phenylethylamine carbonate is precipitated out. This is coupled by the carbodiimide process with N-[(2-adamantyloxy)-carbonyl]-.alpha.-methyl-R-tryptophane.

REFERENCES:
Horwell, D. C., et al., J. Med. Chem., 1991; 34:404-14.

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