Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Reexamination Certificate
2005-04-19
2008-03-11
Gitomer, Ralph (Department: 1657)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
C514S885000
Reexamination Certificate
active
07342125
ABSTRACT:
Novel compounds are disclosed that have the chemical structure of Formula (II), and its prodrug esters and acid-addition salts, and that are useful as Interleukin-1 and Tumor Necrosis Factor-α modulators, and thus are useful in the treatment of various listed diseases.wherein the R groups are defined as provided in the specification. These compounds are useful, for example, as anti-inflammatory analgesics, in treating immune disorders, as anti-cancer and anti-tumor agents, and in the treatment of cardiovascular disease, skin redness, and viral infection. Completely synthetic and semi-synthetic methods of making these compounds are disclosed, as are methods of using these synthetic and semi-synthetic compounds in the treatment of the above-listed disease states.
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Palladino Michael
Theodorakis Emmanuel A.
Gitomer Ralph
Knobbe Martens Olson & Bear LLP
Nereus Pharmaceuticals Inc.
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