Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2003-06-06
2008-03-04
O'Hara, Eileen B. (Department: 1646)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C536S023100, C536S023500, C435S069100
Reexamination Certificate
active
07339028
ABSTRACT:
This invention provides an isolated mahoganoid polypeptide. This invention also provides an isolated mahoganoid nucleic acid, as well as related nucleic acids, pharmaceutical compositions, antibodies, assay methods, therapeutic methods and articles of manufacture.
REFERENCES:
patent: 6001619 (1999-12-01), Beach et al.
patent: 2005/0196754 (2005-09-01), Drmanac et al.
Database UniProt—05.80, Accession No. Q9D074, public availability date Jun. 1, 2001.
Database PIR—80, Accession No. T19204, public availability date Oct. 15, 1999.
Database UniProt—05.80, Accession No. O60291, public availability date Aug. 1, 1998.
Borden, K.L.B., et al. (1996) The RING finger domain: a recent example of a sequence-structure family,Current Opinion in Structural Biology6:395-401 (Exhibit 1).
Bahary, N., et al. (1993) Microdissection of proximal mouse Chromosome 6: identification of RFLPs tightly linked to theobmutation,Mammalian genome4:511-515 (Exhibit 2).
Bultman, S.J., et al. (1993) Molecular Characterization of the Mouse Agouti Locus,Cell71:1195-1204 (Exhibit 3).
Bronson, R.T., et al. (2001) Mice with Mutations in the Mahogany GeneAtrnHave Cerebral Spongiform Changes,Journal of Neuropathology and Experimental Neurology60:724-730 (Exhibit 4).
Conaway, R.C., et al. (2002) Emerging Roles of Ubiquitin in Transcription Regulations,Science296:1254-1258 (Exhibit 5).
Chung, W.K., et al. (1997) Exonic and Intronic Sequence Variation in Human Leptin Receptor Gene (LEPR),Diabetes46:1509-1511 (Exhibit 6).
Dinulescu, D.M., et al. (1998)Mahogany(mg) stimulates feeding and increases basal metabolic rate independent of its suppression ofagouti, Proc. Natl. Acad. Sci. USA95:12707-12712 (Exhibit 7).
Francke, S., et al. (2001) A genome-wide scan for coronary heart disease suggests in Indo-Mauritians a suspectibility locus on chromosome 16p13 and replicates linkage with the metabolic syndrome on 3q27,Human Molecular Genetics10:2751-2765 (Exhibit 8).
Gunn, T.M., et al. (1999) The mousemahoganylocus encodes a transmembrane form of human attractin,Nature398:152-156 (Exhibit 9).
Gunn, T.M., et al. (2001) Molecular and Phenotypic Analysis ofAttractinMutant Mice,Genetics158:1683-1695 (Exhibit 10).
Haskell-Luevano, C. (2001) Agouti-related protein functions as an inverse agonist at a constitutively active brain melanocortin-4 receptor,Regulatory Peptides99:1-7 (Exhibit 11).
He, L., et al. (2001) A biochemical function for attractin in agouti-induced pigmentation and obesity,Nature Genetics27:40-47 (Exhibit 12).
He, L., et al. (2003) Spongiform Degeneration inmahoganoidMutant Mice,Science299:710-712 (Exhibit 13).
Joazeiro, C.A.P., et al. (2000) RING Finger Proteins: Mediators of Ubiquitin Ligase Activity,Cell102:549-552 (Exhibit 14).
Kuramoto, T., et al. (2001) Attractin/Mahogany/Zitter plays a critical role in myelination of the central nervous system,PNAS98:559-564 (Exhibit 15).
Kwon, Y.T., et al. (2001) Constrution and Analysis of Mouse Strains Lacking the Ubiquitin Ligase UBRI (E3α) of the N-End Rule Pathway,Molecular and Cellular Biology21:8007-8021 (Exhibit 16).
Lane, P.W. (1960) New Mutants,Mouse News Letter22: 35-36 (Exhibit 17).
Lane, P.W., et al. (1960) Mahogany, a Recessive Color Mutation in Linkage Group V of the Mouse,J. Hered. 51:228-230 (Exhibit 18).
Leibel, R.L., et al. (1997) The Molecular Genetics of Rodent Single Gene Obesities,The Journal of BiologicalChemistry 272:31937-31940 (Exhibit 19).
Layfield, R., et al. (2001) The ubiquitin protein catabolic disorders,Neuropathology and Applied Neurobiology27:171-179 (Exhibit 20).
Löwer, R. (1999) The pathogenic potential of endogenous retroviruses: facts and fantasies,Trends in Microbiology7:350-356 (Exhibit 21).
Miller, M.W., et al. (1993) Cloning of the mouseagoutigene predicts a secreted protein ubiquitously expressed in mice carrying thelethal yellowmutation,Genes and Development7:454-467 (Exhibit 22).
Miller, K.A., et al. (1997) Genetic Studies of the Mouse Mutationsmahoganyandmahoganoid, Genetics146:1407-1415 (Exhibit 23).
Michaud, E.J., et al. (1994) A molecular model for the genetic and phenotypic characteristics of the mouse lethal yellow (Aγ) mutation,Proc. Natl. Acad. Sci. USA91:2562-2566 (Exhibit 24).
Nagle, D.L., et al. (1999) Themahoganyprotein is a receptor involved in suppression of obesity,Nature398:148-152 (Exhibit 25).
Nijenhuis, W.A.J., et al. (2001) AgRP (83-132) Acts as an Inverse Agonist on the Human-Melanocortin-4 Receptor,Molecular Endocrinology15:164-171 (Exhibit 26).
Nagase, T., et al. (1998) Prediction of the Coding Sequences of Unidentified Human Genes. IX. The Complete Sequences of 100 New cDNA Clones from Brain Which Can Code for Large Proteins in vitro,DNA Research5:31-39 (Exhibit 27).
Ollmann, M.M., et al. (1997) Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein,Science278:135-137 (Exhibit 28).
Pfaffl, M.W., et al. (2002) Real-time RT-PCR quantification of insulin-like growth factor (IGF)-1, IGF-1 receptor, IGF-2, IGF-2 receptor, insulin receptor, growth hormone receptor, IGF-binding proteins 1, 2 and 3 in the bovine species,Domestic Animal Endocrinology22:91-102 (Exhibit 29).
Palmiter, R.D., et al. (1998) Life Without Neuropeptide Y,Recent Progress in Hormone Research53:163-199 (Exhibit 30).
Roderick, T.H., et al. (1976) Chromosome 16 and mahoganoid (md),Mouse News Letter55:16-18 (Exhibit 31).
Saurin, A.J., et al. (1996) Does this have a familiar RING?,TIBS21:208-214 (Exhibit 32).
Seperack, P.K., et al. (1995) Retroviral sequences located within an intron of the dilutegene alter diluteexpression in a tissue-specific manner,The EMBO Journal14:2326-2332 (Exhibit 33).
Venter, J.C., et al. (2001) The Sequence of the Human Genome,Science291:1304-1351 (Exhibit 34).
Weissman, A.M. (2001) Themes and Variation of Ubiquitylation,Molecular Cell Biology2:169-178 (Exhibit 35).
Wolff, G.L., et al. (1978) Phaeomelanin synthesis and obesity in mice,The Journal of Heredity69:295-298 (Exhibit 36).
Yeo, G.S.H., et al. (2000) The role of melanocortin signaling in the control of body weight: evidence from human and murine genetic models,Q.J. Med. 93:7-14 (Exhibit 37); and.
Zheng, N., et al. (2000) Structure of a c-Cb1-UbcH7 Complex: RING Domain Function in Ubiquitin-Protein Ligases,Cell102:533-539 (Exhibit 38).
Phan, L. K. et al. The mouse mahoganoid coat color mutation disrupts a novel C3CH4 RING domain protein. The Journal of Clinical Investigation, vol. 110, No. 5, 1449-1459 (2002); (Exhibit 2).
He, L. et al. Spongiform degeneration in mahoganoid mutant mice. Science Proteins: Structure, Function, and Genetics, vol. 229, 710-712 (2003); (Exhibit 3) and.
International Search Report, Sep. 14, 2004 from the International Search Authority on International Application No. PCT/US03/18138 (Exhibit 4).
Chung Wendy K.
Leibel Rudolph L.
Phan Loan K.
Cooper & Dunham LLP
O'Hara Eileen B.
The Trustees of Columbia University in the City of New York
White John P.
LandOfFree
Mahoganoid polypeptides, and related compositions and methods does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Mahoganoid polypeptides, and related compositions and methods, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mahoganoid polypeptides, and related compositions and methods will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3969747