Cyclic peptides for treatment for cachexia

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Melanotropin or eledoisin; related peptides

Reexamination Certificate

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C530S317000, C530S321000, C530S300000, C530S328000, C530S329000, C514S009100, C514S011400, C514S012200, C514S015800, C514S016700, C514S018700, C424S009100, C436S811000

Reexamination Certificate

active

07342089

ABSTRACT:
A highly selective melanocortin-4 receptor antagonist cyclic peptide of the formulawhere R1, R2, R3, R4a, R4b, R5, R6, R7, x, y and z are as defined in the specification, and a method of treating body weight disorders, including cachexia, sarcopenia and wasting syndrome or disease, and treating inflammation and immune disorders.

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