Heterocyclic compounds useful for inhibition of renin

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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5142272, 5142358, 5142372, 514255, 514269, 514274, 514321, 514322, 514326, 514341, 514343, 514351, 514363, 514369, 514372, 514381, 514384, 514398, 514471, 514473, 544 55, 544123, 544124, 544131, 544315, 544319, 544357, 544360, 544366, 544367, 544370, 544374, 546193, 546194, 546198, 546199, 546208, 546209, 546210, 546211, 546214, 546275, 546276, 546281, 546301, 548136, 548189, 548213, 548251, 5482644, 5483235, 5483241, 549318, C07D21118, C07D40112

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active

053289161

ABSTRACT:
New heterocyclic compounds of the formula

REFERENCES:
patent: 5032577 (1991-07-01), Fang et al.
patent: 5034376 (1991-07-01), Hoover et al.
patent: 5049548 (1991-09-01), Greenlee et al.
RN-122848-91-3 and RN-122848-90-2 of EDP309841 (Sep. 1988) Structural Formula from Chemical Abstract.
Robertson JS "Clinical Aspects of Essential . . . " Elsevier pp. 299-300 (1984).
Kaplan "Clincal Hypertension" Williams & Wilkins pp. 99-100 (1986).
Mountcastle "Medical Physiology" Mosby Co. p. 987 (1968).
Zeffren and Hall "The Study of Enz. Mechanism" WIley p. 87 (1974).
Fleeger, ed., USAN and the USP Dictionary of Drug Names, United States Pharmacopeial Convention, Inc., Rockville, Maryland, 1991, pp. 210, 227.

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