Anti-inflammatory medicament

Details Anti-inflammatory medicament Anti-inflammatory medicament

2001-07-26

2008-01-08

Jiang, Shaojia Anna (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S244000

Reexamination Certificate

active

07317018

ABSTRACT:
The use of adenosine-5′-triphosphate-2′,3′-dialdehyde (oATP) as a medicament useful for the treatment of inflammatory conditions is disclosed.

REFERENCES:
patent: 5847135 (1998-12-01), Bemis et al.
patent: 6096728 (2000-08-01), Collins et al.
Easterbrook-smith et al., (1976) Eur. J. Biochem. vol. 62, pp. 125-130.
Pearce et al., Eur. J. Biochem. vol. 88, pp. 543-554, (1978).
Hu et al., Journal of Biological Chemistry, vol. 273(42), pp. 27170-27175, 1998.
Woolf et al., “Neuropathic pain: aetiology, symptoms, mechanisms, and management” (1999) The Lancet, vol. 353, pp. 1959-1964.
Laliberte et al. “Tenidap Modulates Cytoplasmic pH and Inhibits Anion Transport In Vitro” (1994) J. Immunology, vol. 153, pp. 2168-2179.
Ferrari et al. “Purinergic Modulation of Interleukin-1β Release from Microglial Cells Stimulated with Bacterial Endotoxin” (1997) J. Exp. Med. vol. 185, No. 3, 579-582.
Murgia et al. “Oxidized ATP: An irreversible inhibitor of the Macrophage Purinergic P2z Receptor” (1993) J. Biol. Chem. vol. 268, No. 11, pp. 8199-8203.
The Merck Manual of Diagnosis and Therapy, Seventeenth Edition, Published by Merck Research Laboratories (1999) Beers and Berkow, eds., pp. 1373, 1374, and 1511.
XP-001056870, J. Org. Chem., 1982, O'Donnell et al., “A Mild and Efficient Router to Schiff Base Derivatives of Amino Acids”, pp. 2663-2666.
XP-001056970, Drug Development, 1998, Di Virgilio et al., “Purinergic P2X7Receptor: a Pivotal Role in Inflammation and Immunomodulation”, pp. 207-213.
XP-002191118, American Physiological Society, 1998, Schulze-Lohoff et al., “Extracellular ATP causes apoptosis and necrosis of cultured mesangial cells via P2Z/P2X7receptors”, pp. F962-F979.
XP-002191119, Journal of Biological Chemistry, 1998, Hu et al, “Purinergic Receptor Modulation of Lipopolysaccharide Signaling and Inducible Nitric-oxide Synthase Expression in RAW 264.7 Macrophages”, pp. 27170-27175.
XP-002191120, Journal of Neuroscience, 2000, Liu et al., “Modulation of Interleukin-1β and Tumor Necrosis Factor α Signaling by P2 Purinergic Receptors in Human Fetal Astrocytes”, pp. 5292-5299.
XP-002191121, American Association of Immunologists, 1999, Mutini et al., “Mouse Dentritic Cells Express the P2X7Purinergic Receptor: Characterization and Possible Participation in Antigen Presentation1”, pp. 1958-1965.
XP-002191122, Journal of Cell Science, 1999, Solini et al., “Human primary fibroblasts in vitro express a purinergic P2X7receptor coupled to ion fluxes, microvesicle formation and IL-6 release”, pp. 297-305.
XP-002191123, American Association of Immunologists, 1999, Sikora et al., “Cutting Edge: Purinergic Signaling Regulates Radical-Mediated Bacterial Killing Mechanisms in Macrophages Through a P2X7-Independent Mechanism”, pp. 558-561.
XP-001061622, Virology, 1991, Pizarro et al., “Effect of Nucleotide Analogues on rotavirus Transcription and Republication”, pp. 768-772.

Affiliated with

Also associated with

Rating

Anti-inflammatory medicament does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Anti-inflammatory medicament, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-inflammatory medicament will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3965161