Extracellular/epidermal growth factor like protein

Details Extracellular/epidermal growth factor like protein Extracellular/epidermal growth factor like protein

2004-12-21

2008-07-01

Romeo, David S (Department: 1647)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S350000, C435S069100

Reexamination Certificate

active

07393832

ABSTRACT:
The present invention discloses an extracellular/epidermal growth factor polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include induction of DNA synthesis, stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.

REFERENCES:
patent: 4845075 (1989-07-01), Murray et al.
Campbell et al. Epidermal growth factor-like modules. Curr Opin Struct Biol. 1993, 3:385-392.
Appella et al. Structure and function of epidermal growth factor like regions in proteins. FEBS Lett. Apr. 11, 1988;231(1):1-4.
Brandt et al. Identification and biological characterization of an epidermal growth factor related protein: cripto 1. J Biol Chem. Jun. 24, 1994;269(25):17320-8.
Bowie et al. Deciphering the message in protein sequences: tolerance to amino acid substitutions. Science, (Mar. 16, 1990) 247 (4948) 1306-10.
Ngo et al., in The Protein Folding Problem and Tertiary Structure Prediction, Merz and Le Grand (Eds), Aug. 1994, Springer Verlag, pp. 433 and 492-495.

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