Methods of inhibiting orthopoxvirus replication with...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C514S043000, C514S045000, C514S046000, C514S047000

Reexamination Certificate

active

07323453

ABSTRACT:
The present invention provides methods of inhibiting orthopoxvirus replication and/or treating orthopoxvirus infection with certain nucleoside compounds and derivatives thereof. These compounds are particularly useful as inhibitors of vaccinia virus and variola virus replication and/or for the treatment of vaccinia virus and variola virus infection. The nucleoside compounds may be administered alone or in combination with other agents active against orthopoxvirus infection, in particular against vaccinia virus or variola virus infection. Another aspect of the present invention provides for the use of such nucleoside compounds in the manufacture of a medicament for the inhibition of orthopoxvirus replication and/or for the treatment of orthopoxvirus infection. Yet a further aspect of the present invention provides such nucleoside compounds for use as a medicament for the inhibition of orthopoxvirus replication and/or for the treatment of orthopoxvirus infection.

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De Clerq Clinical Microbiology Reviews (2001), vol. 14, pp. 382-397.
Per Hoffmann, et al., “Recent patents on experimental therapy for hepatitis C virus infection (1999-2002)”, Expert Opin. Ther. Patents [2003] pp. (1707-1723), vol. 13, No. 11.

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