Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1992-09-08
1994-07-12
Kepplinger, Esther L.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 78, 435948, 435968, G01N 33567
Patent
active
053288300
ABSTRACT:
An assay for detecting molecules and compounds which specifically bind to sites which regulate cellular potassium channels, for use, inter alia, as a method for identifying drugs with activity specific for modulating K.sup.+ channels.
REFERENCES:
patent: 4567188 (1986-01-01), Niemers et al.
Bray et al., 1992, J. Biol. Chem., 267:11689 "A Specific Binding Site for K+ Channel Openers in Rat Aorta".
Quast et al., 1992, Japanese J. Pharm., 58:226P, "Identification of a Specific Binding Site for K+".
"Channel Openers in Rat Aorta".
French et al., Modulation of [.sup.3 H] Glibenclamide Binding to Cardiac and Insulinoma Membranes. Eur. J. Pharmacology 207(1):23-28, 1991.
Hoffman, Jr. Frederick J.
Janis Ronald A.
Kepplinger Esther L.
Miles Inc.
Wortman Donna C.
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