Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2008-05-27
2008-05-27
Horlick, Kenneth R. (Department: 1637)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091100
Reexamination Certificate
active
11605826
ABSTRACT:
This disclosure provides methods for detecting and localizing DNA mutations by DNA microarray. In various embodiments, the described methods include use of restriction endonuclease(s) and/or mismatch-recognition nuclease(s) to detect and/or localize mutations. In one representative method, reference and target DNA are digested using one or more restriction endonucleases, resultant DNA strands are labeled (e.g., using a DNA polymerase), and the labeled mixture of DNAs is hybridized to a microarray. In another representative method, reference and target DNA are denatured and annealed to form a mixture containing heteroduplex DNA, one or more mismatch-recognition nuclease(s) are used to nick or cleave at least a portion of the heteroduplex DNA, resultant DNA strands are labeled (e.g., using a DNA polymerase) and the labeled mixture of DNAs is hybridized to a microarray.
REFERENCES:
patent: 4794075 (1988-12-01), Ford et al.
patent: 5698400 (1997-12-01), Cotton et al.
patent: 5723320 (1998-03-01), Dehlinger
patent: 5728524 (1998-03-01), Sibson
patent: 5750335 (1998-05-01), Gifford
patent: 5922535 (1999-07-01), Huo
patent: 6468742 (2002-10-01), Nerenberg
patent: 6713258 (2004-03-01), Kilian
patent: 6783943 (2004-08-01), Christian et al.
patent: 6924104 (2005-08-01), Weissman et al.
patent: 2002/0146723 (2002-10-01), Krontiris et al.
patent: 2003/0186279 (2003-10-01), Kennedy
patent: 2004/0048257 (2004-03-01), Liu
patent: 2005/0032082 (2005-02-01), Kilian
patent: 2005/0064406 (2005-03-01), Zabarovsky
patent: WO 99/31272 (1999-06-01), None
patent: WO 00/34518 (2000-06-01), None
patent: WO 00/44936 (2000-08-01), None
patent: WO 00/50632 (2000-08-01), None
patent: WO 00/55364 (2000-09-01), None
patent: WO 02/083955 (2002-10-01), None
patent: WO 2004/044225 (2004-05-01), None
Buckley, “Development and Application of Microarray-Based Comparative Genomic Hybridization: Analysis of Neurofibromatosis Type-2, Schwannomatosis and Related Tumors,” Abstract for Doctoral Thesis from Uppsala University,Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine(Feb. 2005).
Chee et al., “Accessing Genetic Information with High-Density DNA Arrays,”Science, 274(5287):610-614 (Oct. 1996).
Gotoh and Oishi, “Screening of Gene-Associated Polymorphisms by Use of In-Gel Competitive Reassociation and EST (cDNA) Array Hybridization,”Genome Research, 13:492-495 (2003).
Hacia, “Resequencing and mutational analysis using oligonucleotide microarrays,”Nature Genetics Supplement, 21:42-47 (Jan. 1999).
Jaccoud et al., “Diversity Arrays: a solid state technology for sequence information independent genotyping,”Nucleic Acids Research, 29 (4): 1-7 (2001).
Jingfeng et al., “NotI subtraction and NotI-specific microarrays to detect copy number and methylation changes in whole genomes,”PNAS USA99(16):10724-10729 (Aug. 6, 2002).
Liu et al., “SNP selection for a microarray based high-throughput genotyping assay,” Abstract for a poster presented at Jul. 31-Aug. 4, 2004, meeting—12thInternational Conference on Intelligent Systems for Molecular Biology (accessible on-line at the website iscb.org/ismb2004/posters/guoying—liuATaffymetrix.com—463.html).
Lucito et al., “Representational Oligonucleotide Microarray Analysis: A High-Resolution Method to Detect Genome Copy Number Variation,”Genome Research, 13:2291-2305 (2003).
Martin et al., “A rapid method to map mutations inDrosophila,” Genome Biology, 2(9):1-12 (Aug. 2001).
Wang et al., “Large-Scale Identification, Mapping, and Genotyping of Single-Nucleotide Polymorphisms in the Human Genome,”Science, 280:1077-1082 (May 1988).
Horlick Kenneth R.
Klarquist & Sparkman, LLP
State of Oregon Acting by and Through the State Board of Higher
LandOfFree
Methods for detecting and localizing DNA mutations by... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for detecting and localizing DNA mutations by..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for detecting and localizing DNA mutations by... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3957008