Classifying – separating – and assorting solids – Fluid suspension – Liquid
Reexamination Certificate
2008-07-29
2008-07-29
Mackey, Patrick (Department: 3654)
Classifying, separating, and assorting solids
Fluid suspension
Liquid
C209S210000, C137S56100R
Reexamination Certificate
active
11152975
ABSTRACT:
The present invention relates to an improved apparatus and method for assembly for a cylindrical split-flow thin separation channel that is capable of continuously separating particles of interest from a suspension flowing through the channel. The apparatus provides better precision in the separation process by providing better flow characteristics at the inlet, outlet, and in the zone of separation. Splitter surfaces are provided that match the calculated theoretical Inlet Splitter Surface (ISS) and Outlet Splitter Surface (OSS). A flow distributor diverts the inlet carrier flow into a stable, circumferentially uniform, laminar annular flow. The design enables manufacturing and assembly methods to ensure precise alignment of the components to further improve the flow profiles within the separation channel and to ensure repeatability device-to-device.
REFERENCES:
patent: 4141809 (1979-02-01), Aitchison et al.
patent: 5039426 (1991-08-01), Giddings
patent: 5968820 (1999-10-01), Zborowski et al.
patent: 6120735 (2000-09-01), Zborowski et al.
patent: 6312910 (2001-11-01), Vellinger et al.
patent: 6365050 (2002-04-01), Cauchon
patent: 6467630 (2002-10-01), Zborowski et al.
patent: 6623984 (2003-09-01), Fleischman et al.
patent: 6688473 (2004-02-01), Franzreb et al.
patent: 6699669 (2004-03-01), Vellinger et al.
patent: 9838293 (1998-09-01), None
Fuh, et al., “Hydrodynamic Characterization of SPLITT Fractionation Cells,” Separation Science and Technology, 30(20), pp. 3861-3876, Marcel Dekker, Inc., 1995.
Hoyos, et al., “Pulse-Injection Studies of Blood Progenitor Cells in a Quadropole Magnetic Flow Sorter,” J. Separation Science and Technology, 37(4), 1-23. 2002.
Hoyos, et al., “Study of Magnetic Particles Pulse-Injected Into an Annular SPLITT-Like Channel Inside a Quadrupole Magnetic Field,” J. Chromatogr., A, 903 (1-2), 99-116, 2000.
Lara et al., “Enrichment of Rare Cancer Cells Through Depletion of Normal Cells Using density and Flow-Through, Immunomagnetic Cell Separation,” Experimental Hematoloty 32, pp. 891-904, Elsevier, Inc., 2004.
Lara et al., “Negative Depletion Cell Sorting Using a Quadrupole Magnetic Cell Sorter,” European Cells and Materials, vol. 3. Supple. 2, pp. 62-64. 2002.
McCloskey, et al., “Magnetophoretic Mobilities Correlate to Antibody Binding Capacities,” Cytometry. vol. 40, Issue 4, pp. 307-315, Apr. 2000, Wiley-Liss, Inc.
Moore, et al., “Progenitor Cell Isolation with a High-Capacity Quadrupole Magnetic Flow Sorter,” J. Magn. Magn. Mater. 225 (1-2): 277-284. 2001.
Myers, “Overview of Field-Flow Fractionation,” Journal of Microcolumn Separations, vol. 9, Issue 3, pp. 151-162, Jan. 1997, John Wiley & Sons, Inc.
Nakamura, et al., “Separation of a Breast Cancer Cell Line from Human Blood Using a Quadrupole Magnetic Flow Sorter,” Biotechnol. Prog. 17, pp. 1145-1155, 2001.
Sun, et al., “Continuous, Flow-Through Immunomagnetic Cell Sorting in a Quadrupole Field,” Cytometry 33, pp. 469-475, Wiley-Liss, Inc., 1998.
Williams, et al., “Flow Rate Optimization for the Quadrupole Magnetic Cell Sorter,” Analytical Chemistry, 71:3799-3807, 1999.
Williams, et al., “The Potential of Quadrupole magnetic Field-Flow Fractionation for Determining Particle Magnetization Distributions,” European Cells and materials, vol. 3, Supple. 2, pp. 203-205, 2002.
Williams, et al., “Splitter Inperfections in Annular Split-Flow Thin Separation Channels: Effect on Nonspecific Crossover,” Analytical Chemistry, vol. 75, No. 6, Mar. 15, 2003, pp. 1365-1373.
Zborowski, et al., “Continuous Cell Separation Using Novel Magnetic Quadrupole Flow Sorter,” Journal of Magnetism and Magnetic Materials, 194, pp. 224-230, 1999.
Zhang, et al., “General Theory for Flow Optimisation of Split-Flow Thin Fractionation” Journal of Chromatography A., 1010 pp. 87-94, Elsevier, Inc., 2003.
Kennedy David J.
Taylor Eric W.
Vellinger John C.
Eichenberger Robert H.
Killmeier Eric L.
Mackey Patrick
Matthews Terrell
Middleton & Reutlinger
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