Minimally invasive, sustained, intra-tympanic drug delivery...

Surgery – Instruments – Means for inserting or removing conduit within body

Reexamination Certificate

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C604S275000, C604S035000

Reexamination Certificate

active

11039556

ABSTRACT:
A convenient and preferably wearable system and method for implementing the controlled and sustained delivery of a medical liquid through the tympanic membrane and into the middle ear including port structure that produces a minimal opening in the membrane, a wearable and fixated fluid-conduit structure coupleable to the port structure, a reservoir adapted to contain delivery fluid, and an operationally controllable pump system applied to the fluid conduit structure, and/or an iontophoretic electrode system applied within the fluid conduit structure and to the subject's body, and operable to effect the delivery of reservoir-held fluid or medically active ions through the fluid conduit and port structures to the middle ear.

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Wearne et al., “Control of Spatial Orientation of the Angular Vistibulocular Reflex by the Nodulus and Uvula”, J. Neurophysiol. 79:2690-2715 (1998).

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