Process for the production of β-amino acids using acylase

Details Process for the production of β-amino acids using acylase Process for the production of β-amino acids using acylase

2008-04-01

2008-04-01

Prouty, Rebecca E. (Department: 1652)

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

C435S069100, C435S106000, C435S252300, C536S023200

Reexamination Certificate

active

11198242

ABSTRACT:
The present invention relates to aVariovoraxsp. which produces an acylase having an asymmetric hydrolysis activity on an N-acetyl β-amino acid to selectively produce an R-β-amino acid, and aBurkholderiasp. which produces both an acylase having an asymmetric hydrolysis activity on an N-acetyl β-amino acid to selectively produce an S-β-amino acid and an acylase having an asymmetric hydrolysis activity of an N-acetyl β-amino acid to selectively produce an R-β-amino acid, and a process for the selective production of an S-, or R-β-amino acid using the above strains.

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Gröger, H., et al., “The first aminoacylase-catalyzed enantioselective synthesis of aromatic β-amino acids,” Org. Biomol. Chem. 2004;2(14):1977-1978.
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Soloshonok, V.A., et al., “Biocatalytic Approach to Enantiomerically Pure β-Amino Acids,” Tetrahedron:Asymmetry 1995;6(7):1601-1610.

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