Phenylcarboxylate beta-secretase inhibitors for the...

Details Phenylcarboxylate beta-secretase inhibitors for the... Phenylcarboxylate beta-secretase inhibitors for the...

2008-03-25

2008-03-25

Eyler, Yvonne (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Sulfinate esters

C558S411000

Reexamination Certificate

active

10562470

ABSTRACT:
The present invention is directed to compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the beta-secretase enzyme is involved.

REFERENCES:
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patent: WO 89/04833 (1989-06-01), None
patent: WO 01/00665 (2001-01-01), None
patent: WO 03/072535 (2003-09-01), None
patent: WO 03/106405 (2003-12-01), None
patent: WO 2005/053374 (2005-01-01), None
C. A. Coburn et al., “Identification of a Small Molecule Nonpeptide Active Site Beta-Secretase Inhibitor That Displays a Nontraditional Binding Mode for Aspartyl Proteases,” J. Med. Chemistry, vol. 47, pp. 6117-6119 (2004).
E. Rubini et al., “Synthesis of Isosteric Methylene-Oxy Pseudodipeptide Analogues As Novel Amide Bond Surrogate Units,” Tetrahedron, vol. 42, No. 21, pp. 6039-6045 (1986).
CAPLUS Abstract 113:40174.
CAPLUS Abstract 139:230480.
CAPLUS Abstract 136:232115.

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