Methods and devices for droplet microchromatography

Details Methods and devices for droplet microchromatography Methods and devices for droplet microchromatography

2008-04-29

2008-04-29

Le, Long V. (Department: 1641)

Chemical apparatus and process disinfecting, deodorizing, preser

Analyzer, structured indicator, or manipulative laboratory...

Sample mechanical transport means in or for automated...

C435S004000, C435S007100, C435S287100, C435S287200, C422S050000, C422S051000, C073S061710, C073S061770

Reexamination Certificate

active

11469934

ABSTRACT:
Disclosed devices and methods for droplet microchromatograhy are aimed at optical monitoring and rapid analysis of a drying droplet. The device includes droplet deposition component preferably made as a modified disk adapted to fit in a modified CD disk drive, an optical recorder, and a computer control and image analysis. Recorded timed sequence of images of the process of drying of the droplet is digitally filtered and analyzed using windows selected in each image. Changes of predetermined parameters in each window for each image are calculated to assess temporal and spatial dynamics within the sequence of images reflecting sedimentary pattern formation of a drying droplet. Humidity can be selectively controlled to slow down the drying process allowing “zooming” onto the critical periods of drying of the droplet. Various chemical coatings of the deposition means can be used to enhance the test further. If used with biological fluids, the devices and methods of the invention can provide for rapid diagnosis of a variety of conditions and diseases.

REFERENCES:
patent: 6808934 (2004-10-01), Mutz et al.
patent: 2002/0168699 (2002-11-01), Thompson et al.
patent: 2003/0059849 (2003-03-01), Sugahara et al.
patent: 2004/0053340 (2004-03-01), De Haard et al.
patent: 2004/0218804 (2004-11-01), Affleck et al.
Yakhno et al., On the Existence of Regular Structures in Liquid Human Blood Serum (Plasma) and Phase Transitions in the Course of Its Drying, 2003, Technical Physics, vol. 48, No. 4, pp. 23-27.

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